Incorporation of a Hypertension Working Group into the Jackson Heart Study

根据最近的发现，研究2020年非裔美国成年人的高血压比以往任何时候都更加重要 54%的非裔美国成年人患有高血压，只有19%的人血压控制在 指南推荐水平，血压升高和高血压占心血管疾病的33% (CVD)非裔美国人中的事件。2030年美国心脏协会(AHA)的影响目标是 在接下来的十年里，将美国成年人的健康调整后预期寿命增加3年。健康调整后的生活 与白人成年人相比，非裔美国人的预期寿命更短，我们来自 杰克逊心脏研究(JHS)表明，患有心脏病的非裔美国成年人比不患有心脏病的非裔美国成年人的寿命短7年 高血压。在本申请中，我们建议更新JHS高血压工作组(JHS- HWG)，它将解决非裔美国人中新的高度优先的BP研究问题，并有助于 指导高血压研究的早期研究人员(Esis)。鉴于其样本量大和广泛性 表型，JHS是解决高血压的几个知识空白的理想环境 非裔美国人。2000至2004年间，5,306名非洲裔美国人参加了JHS并完成了 基线研究访问，包括临床血压测量和关于社会决定因素的问卷调查 健康和健康行为。已经进行了三次研究访问，当时高血压发作和 对脏器损伤进行评估。参与者在心血管事件中接受了超过16年的跟踪调查。在过去的时间里 两个供资周期(7年)，30个JHS-HWG Esis，包括16名任职人数不足的少数族裔调查员 出版了48篇稿件，其中6篇稿件正在接受同行评审。JHS-HWG Esis已成功 获得赠款资金，包括4个R01奖，7个职业发展奖(6个来自NIH，1个 来自AHA)，三个多样性补充剂，和一个博士前F31奖。在下一个赠款周期中，我们 建议在四个核心专题领域进行研究：(1)健康和风险的社会决定因素 高血压和血压控制；(2)高血压和血压控制的健康行为和风险；(3)比较 非洲裔美国人与非洲黑人的高血压研究；(4)冲击性高血压 预防和控制血压增加了健康调整后的预期寿命。Esis的新培训活动 包括介绍跨学科团队科学、职业发展规划、拨款申请 研讨会、同龄人小组辅导和写作责任小组。此外，我们将为以下人员提供职业培训 前JHS-HWG高管现已进入职业生涯中期。JHS-HWG将由主要调查人员领导，他们已经 有很强的合作历史，在发表高影响力的高血压研究方面有既定的记录 以及指导艾西斯。通过JHS-HWG，我们的目标是找到预防高血压的方法，改善 控制血压并增加非裔美国人的健康调整预期寿命，同时提供创新的 为下一代高血压研究人员提供培训和职业发展机会。

Studying hypertension in African-American adults in 2020 is more important than ever in light of recent findings that 54% of African American adults have hypertension, only 19% have their blood pressure (BP) controlled to guideline recommended levels, and elevated BP and hypertension account for 33% of cardiovascular disease (CVD) events among African Americans. The 2030 American Heart Association (AHA) impact goal is to increase the health-adjusted life expectancy of US adults by 3 years over the next decade. Health-adjusted life expectancy is shorter in African Americans compared with white adults and our preliminary data from the Jackson Heart Study (JHS) indicates its 7 years shorter among African American adults with versus without hypertension. In this application, we propose the renewal of the JHS Hypertension Working Group (JHS– HWG), which will address new high priority BP research questions in African Americans and also serve to mentor early stage investigators (ESIs) in hypertension research. Given its large sample size and extensive phenotyping, the JHS is the ideal setting for addressing several knowledge gaps in hypertension among African Americans. Between 2000 and 2004, 5,306 African Americans were enrolled in the JHS and completed a baseline study visit that included clinic BP measurements and questionnaires on social determinants of health and health behaviors. Three study visits have been conducted at which time hypertension onset and organ damage were assessed. Participants have been followed over 16 years for CVD events. Over the past two funding cycles (7 years), 30 JHS-HWG ESIs, including 16 under-represented minority investigators, have published 48 manuscripts with 6 manuscripts undergoing peer review. JHS-HWG ESIs have successfully obtained grant funding including four R01 awards, seven career development awards (six from NIH and one from AHA), three diversity supplements, and one pre-doctoral F31 award. For the next grant cycle, we propose to conduct research in four core thematic areas: (1) social determinants of health and risk for hypertension and BP control; (2) health behaviors and risk for hypertension and BP control; (3) comparative research on hypertension in African Americans versus black Africans; and (4) the impact hypertension prevention and BP control has on increasing health adjusted life expectancy. New training activities for ESIs include an introduction to interdisciplinary team science, career development planning, grant writing workshops, group peer mentoring, and writing accountability groups. Also, we will provide career training for former JHS-HWG ESIs that are now mid-career. The JHS-HWG will be led by principal investigators, who have a strong collaborative history, and an established track record of publishing high impact hypertension research and mentoring ESIs. Through the JHS-HWG, we aim to identify approaches to prevent hypertension, improve BP control and increase health-adjusted life expectancy among African Americans while providing innovative training and career development opportunities for the next generation of hypertension researchers.