THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE

项目摘要 NIA建立了阿尔茨海默病国家衰老遗传学研究所数据存储网站 (NIAGADS)作为国家遗传学数据库，以便利合格的研究人员访问 晚发性阿尔茨海默病(AD)遗传学研究的基因分型数据。这是NIA的政策 所有来自NIA资助的迟发性阿尔茨海默病遗传学研究的基因数据 尽可能存放在NIAGADS或其他NIA批准的地点或两者都有。NIAGADS也是数据 阿尔茨海默病测序项目协调中心(ADSP)，国家老龄研究所 通过对30,000多名AD患者的基因组/外显子基因组测序来确定新的遗传变异的倡议和 认知正常的对照组。在第三个资助期，NIAGADS将继续我们的主要使命 国家AD遗传学和基因组学存储库，支持ADSP数据协调，并与NIA- 资助和其他相关的ADRD研究倡议。不断增长的数据将演变为一种持久的资源 也是ADSP的一项主要遗产。NIAGADS将：(1)管理、更新和传播高质量、持久的数据 收集8万个或更多基因组，用于ADRD遗传学/基因组学研究；(2)支持ADSP数据 生产和分析活动；(3)为基于云的数据分析开发信息学基础设施， 管理和传播；(4)扩大遗传和基因组数据注释的计算工具， 报告和可视化；(5)与其他研究资源和倡议合作，扩大外展 程序。

Project Summary NIA has established the National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) as a national genetics data repository in order to facilitate access by qualified investigators to genotypic data for the study of the genetics of late-onset Alzheimer's Disease (AD). It is the policy of the NIA that all Genetic Data derived from NIA funded studies for the genetics of late-onset Alzheimer's disease be deposited at NIAGADS or another NIA approved site or both whenever possible. NIAGADS is also the Data Coordinating Center for Alzheimer's Disease Sequencing Project (ADSP), a National Institute on Aging initiative to identify new genetic variants by sequencing genomes/exomes of more than 30,000 AD patients and cognitively normal controls. In the third funding period, NIAGADS will continue our primary mission as the national repository for AD genetics and genomics, support ADSP data coordination, and collaborate with NIA- funded and other relevant ADRD research initiatives. The growing data will evolve into a long-lasting resource and a major legacy of ADSP. NIAGADS will: (1) Curate, update, and disseminate a high-quality, lasting data collection with 80,000 or more genomes for ADRD genetics/genomics research; (2) Support ADSP data production and analysis activities; (3) Develop informatics infrastructure for cloud-based data analysis, management and dissemination; (4) Expand computational tools for genetic and genomic data annotation, report and visualization; (5) Collaborate with other research resources and initiatives, and expand the outreach program.