Antibody Neutralization Mechanisms

高效中和抗体可用于预防或治疗HIV-1、疟疾和其他人类病原体感染。我们对hiv -1中和抗体的大部分工作都集中在鉴定、表征和在许多情况下改进自然引发的抗体上。改进的抗体包括cd4结合位点定向抗体，能够中和95%以上的HIV。最近，我们开发了cd4结合位点抗体的改变，其效力增强，多反应性降低。其他cd4结合位点抗体正在生产和临床评估中。我们还与其他小组合作，确定针对其他高度多样化的人类病原体的广泛中和抗体；具体来说，我们还分析了疫苗接种者对诺如病毒具有广泛阻断作用的抗体和对甲型流感病毒具有广泛中和作用的抗体。因此，我们的抗体相关工作包括了解和改进抗体，作为治疗HIV-1和其他人类病原体的可能药物。

Highly effective neutralizing antibodies could have utility in the prevention or treatment of infection from HIV-1, malaria, and other human pathogens. Much of our work with HIV-1-neutralizing antibodies has focused on identifying, characterizing and in many case improving naturally elicited antibodies. Improved antibodies include versions of CD4-binding site-directed antibodies capable of neutralizing over 95% of HIV. Recently, we developed alterations of CD4-binding site antibodies which have increased potency and reduced polyreactivity. Other CD4-binding site antibodies are being manufactured and assessed clinically. We are also working in collaboration with other groups to identify broadly neutralizing antibodies against other highly diverse human pathogens; specifically, we have also analyzed vaccinees for antibodies with broad blockade against norovirus and for antibodies with broadly neutralizing activity against influenza A virus. Thus our antibody-related work involves understanding and improving antibodies, as possible therapeutic agents against HIV-1 and other human pathogens.