Colorado Clinical and Translational Sciences Institute: UL1 Diversity KL2 Supplement

首席调查员(最后、第一、中间)：索科尔、罗纳德(多元化候选人：麦克尼尔、德米特里亚、密歇根) 摘要 NCATS资助的UL1项目摘要 由美国国立卫生研究院于2008、2013和2018年资助的科罗拉多州临床和翻译科学研究所(CCTSI) 科罗拉多大学安舒茨医学院(CUAMC)改变和改进了生物医学； 科罗拉多地区的研究和培训企业，并加速和催化了 在改善病人护理和公共卫生方面的发现。CCTSI是由CUAMC、CU Boulder、 科罗拉多州立大学、6家医院和20个社区组织建立了新的基础设施， 精简程序，扩大调查人员和利益攸关方的现有资源和服务； 支持翻译队伍发展的培训和教育项目数量增加了两倍； 促进团队科学和跨学科研究；建立广泛的社区参与 计划；为临床和翻译科学家和实习生创建了学术之家；并积极参与 CTSA网络活动。CCTSI有五个总体战略目标： 目标1：培养、教育和维持一支多样化的翻译科学队伍，以确保最高水平的研究 创新、质量、安全。 目标2：创造一个团队科学以及地方和国家合作的翻译研究环境 得到了便利、支持和重视。 目标3：让地方和国家社区和利益攸关方参与翻译研究的所有阶段 进程。 目标4：创造新的方法和资源，支持和整合特殊人群的研究， 包括儿童、老年人、服务不足的人和患有罕见疾病的人。 目标5：进一步创新和精简我们的流程，增强我们的信息学研究能力 启动、实施和监督，以促进我们的研究和活动的质量、效率和安全 参与国家CTSA试验创新网络。 麦克尼尔博士的建议充分利用了CCTSI的目标一和目标四，以及它们在 遵循以下方式。第一，为支持实现CCTSI目标1，CCTSI制定了新的方案和 提供旨在支持早期职业教师发展的资源。现有计划和 资源为麦克尼尔博士创造了理想的环境，他是一名初级和少数族裔教职员工，可以 作为一名独立学者而茁壮成长。为了准备这份报告，麦克尼尔博士已经参与了一次 CCTSI赞助的项目(CCTSI Research Studio)，在该项目中，一支跨学科的高级学者团队 审阅该项目提案并提供反馈，以进一步完善研究问题和方法。 麦克尼尔博士竞争激烈地被选中参加两个研究和职业发展项目： 美国国立卫生研究院计划增加从事健康相关工作的个人的多样性 研究(PROCE)和CCTSI赞助的临床教师学者计划。此外，麦克尼尔博士还有 完成了两个Atlas.ti课程，学习定性数据的软件管理。支持学习 指导计划中确定的机会(参见图2)，McNeal博士将有权访问这两门课程 并在颁奖过程中亲身体验。CCTSI的具体培训包括课程作业 通过临床科学研究生计划，KL2职业发展中的每月会议，预科 格兰特审查计划和研究工作室。麦克尼尔博士将使用的其他CCTSI培训包括 监管知识和支持、礼宾提交和招聘参与者(见表3)。第二，在 与CCTSI目标4相一致，这项研究明确关注服务不足的人群。麦克尼尔博士是 调查黑人和西班牙裔美国人的人口。该项目将确定潜在的临床医生和 与患者相关的因素，导致医疗结果的健康差异和医疗服务的不平等 在患有外周动脉疾病(PAD)的非裔美国人和西班牙裔患者中。这是一个重要的和 新项目是解决健康差距的第一步，非常适合家长U1赠款 以及CCTSI的职能。

Principal Investigator (Last, first, middle): Sokol, Ronald (Diversity Candidate: McNeal, Demetria, M) SUMMARY Abstract of NCATS-Funded UL1 Project Funded by NIH in 2008, 2013 and 2018 the Colorado Clinical and Translational Sciences Institute (CCTSI) at the University of Colorado Anschutz Medical Campus (CUAMC) has transformed and improved the biomedical; research and training enterprise in the Colorado region and accelerated and catalyzed the translation of discoveries into improved patient care and public health. The CCTSI, a partnership of CUAMC, CU Boulder, Colorado State University, six hospitals and 20 community organizations, has established new infrastructure, streamlined processes and expanded existing resources and services for investigators and stakeholders; tripled the number of training and education programs supporting development of a translational workforce; promoted team science and interdisciplinary research; established an extensive community engagement program; created an academic home for clinical & translational scientists and trainees; and actively engaged in CTSA network activities. CCTSI has five overall strategic goals: Goal 1: Develop, educate and sustain a diverse translational science workforce to ensure the highest research innovation, quality and safety. Goal 2: Create a translational research environment in which team science and local and national collaboration are facilitated, supported and valued. Goal 3: Engage local and national communities and stakeholders in all phases of the translational research process. Goal 4: Create novel methodologies and resources to support and integrate research in special populations, including children, the elderly, the underserved and those with rare diseases. Goal 5: Further innovate and streamline our processes and enhance our informatics capacity for research start-up, implementation and oversight to promote quality, efficiency, & safety of our research and our active participation in the national CTSA Trial Innovation Network. Dr. McNeal's proposal capitalizes on CCTSI's goals one and four and their accompanying resources in the following ways. First, to support attainment of CCTSI goal 1, the CCTSI has established new programs and offers resources designed to support the development of early stage career faculty. Existing programs and resources create the ideal environment for Dr. McNeal, a junior and minority faculty member, to advance and thrive as an independent scholar. To prepare for this submission, Dr. McNeal has already participated in one CCTSI sponsored program (CCTSI Research Studio) in which a team of interdisciplinary senior scholars reviewed this project proposal and provided feedback to further refine the research question and methodology. Dr. McNeal has been competitively selected to participate in two research and career development programs: The National Institutes of Health Programs to Increase Diversity Among Individuals Engaged in Health-Related Research (PRIDE) and the CCTSI-sponsored Clinical Faculty Scholars Program. Additionally, Dr. McNeal has completed two Atlas.ti courses to learn software management for qualitative data. To support learning opportunities identified in the Mentoring Plan (see figure 2), Dr. McNeal will have access to both coursework and hands on experiences over the course of the award period. Specific CCTSI training includes course work through the Clinical Sciences Graduate Program, the KL2 career in progress monthly meetings, the Pre-K grant review program and the Research Studio. Additional CCTSI trainings that Dr. McNeal will use include Regulatory Knowledge and Support, Protocol Submission and Recruiting Participants (see table 3). Second, in alignment with CCTSI goal 4, the study has an explicit focus on underserved populations. Dr. McNeal is investigating Black and Hispanic American populations. The project will identify underlying clinician and patient related factors that contribute to health disparities in outcomes and health inequities in care delivery among African American and Hispanic patients with peripheral artery disease (PAD). This is an important and novel project that is the first step in addressing health disparities and fits very well within the Parent U1 grant and the functions of the CCTSI.