False Memories in Alzheimer's Disease

许多退伍军人阿尔茨海默病患者存在轻度认知障碍和轻度痴呆 舞台在社区中独自生活。尽管人们已经知道100多年了，但忘记了 干扰了他们的生活质量，我们已经获得了新的数据，证明了错误率 阿尔茨海默病患者的记忆力极高--几乎和健忘一样高。这笔赠款的目的是 是为了了解错误记忆的生理和认知基础及其临床和 日常生活中的功能暗示。我们需要了解错误记忆会在多大程度上影响 AD患者的日常生活。我们需要确定错误记忆的好模型 与真实世界中的错误记忆相关的实验室。我们需要使用这些模型来 了解错误记忆的认知和生理基础，并尝试不同的 减少错误记忆的策略、辅助手段和技术。 为了实现这些目标，我们计划进行以下研究。实验1将检验 错误记忆与遗忘之间的相关性(使用标准问卷和新式问卷) 阿尔茨海默病患者的日常生活能力和生活质量(使用标准问卷)。 实验2将考察日常生活中错误记忆之间的相关性(使用一本小说 问卷)和几种阿尔茨海默病患者的实验错误记忆范式。实验 3将使用标准的神经心理学测试来检查错误背后的认知域 阿尔茨海默病患者的记忆。实验4将使用新的行为实验记忆 研究阿尔茨海默病患者错误记忆的记忆成分的范例。 实验5将使用一种新的事件相关电位(ERP)错误记忆范式来检查 阿尔茨海默病患者错误记忆的生理基础一旦这些目标实现了 完成后，我们将准备好应用这些方法来减少日常生活中的错误记忆 患有AD的退伍军人。 我们之前的VA Merit研究致力于更好地理解对 阿尔茨海默病患者在实验室。本提案建立在先前工作的基础上，并采取了重大的 向前迈进一步，旨在了解日常生活中的错误记忆与日常生活中的错误记忆之间的关系 实验室，以及认知功能、大脑生理学和--最重要的--生活质量。 一旦了解了这些关系，错误记忆的实验室模型就可以用来 合理设计干预措施，减少日常生活中AD患者的虚假记忆， 提高患者及其家属的生活质量。

Many Veterans with Alzheimer’s disease in the mild cognitive impairment and mild dementia stages live alone in the community. Although it has been known for over 100 years that forgetting interferes with their quality of life, we have obtained new data demonstrating that rates of false memories in those with AD are extremely high—almost as high as forgetting. The goal of this grant is to understand the physiological and cognitive basis of false memories and their clinical and functional implications in daily life. We need to understand to what degree false memories impact the daily life of patients with AD. We need to determine good models of false memories in the laboratory that correlate with false memories in the real world. We need to use those models to understand the cognitive and physiological bases of false memories, and to try out different strategies, aids, and techniques to reduce false memories. To accomplish these goals we plan to do the following studies. Experiment 1 will examine the correlation between false memories and forgetting (using standard and novel questionnaires) with activities of daily living and quality of life (using standard questionnaires) in patients with AD. Experiment 2 will examine the correlation between false memories in daily life (using a novel questionnaire) and several experimental false memory paradigms in patients with AD. Experiment 3 will use standard neuropsychological tests to examine the cognitive domains that underlie false memories in patients with AD. Experiment 4 will use novel behavioral experimental memory paradigms to examine the memory components that underlie false memories in patients with AD. Experiment 5 will use a novel event-related potential (ERP) false memory paradigm to examine the physiological basis of false memories in patients with AD. Once these goals have been accomplished, we will be ready to apply these methods to reduce false memories in the daily life of Veterans with AD. Our prior VA Merit research worked to better understand true and false memories of patients with AD in the laboratory. The present proposal builds on the prior work and takes a major step forward, aiming to understand how false memories in daily life relate to false memories in the laboratory, as well as to cognitive function, brain physiology, and—most importantly—quality of life. Once these relationships are understood, laboratory models of false memories can be utilized to rationally design interventions that can reduce false memories in the daily life patients with AD, improving quality of life for patients and their families.