8th International Symposium on Collaterals to the Brain

项目摘要/摘要 第八届脑络脉国际学术会议是一次多学科的科学会议，主要研究缺血性卒中的侧支循环。这项提议要求部分支持召开一次具有广泛、长期目标的会议，该会议将推进当前对侧支循环血流的研究，并确定世界各地当前治疗策略的差距。侧支循环或个体抵消脑缺血的能力，以及确定有利的侧支循环已成为考虑脑缺血和卒中驱动个性化医疗决策的精确医学的关键因素。这次会议直接解决了在最佳定义附属状态方面最紧迫的问题和空白，这些问题和空白限制了中风疗法在世界各地的实现。决定性的挑战包括：确定治疗缺血性中风的最佳分类和基于侧支状态的选择范例的普遍性，专家方法和变革性进展的迅速传播，以及迫切需要利用与脑络脉血流动力学相关的中风教育和科学的网络机会。这次会议的目的是召集来自世界各地的教职员工，将这个最先进设施的现场参与者与超过75个国家和地区的远程观众联系起来。详细的演讲主题围绕与脑络的基础科学、翻译、临床研究、常规临床方面、成像、血管内治疗和护理系统问题有关的主题安排。这次为期3天的会议的确认计划被组织成40分钟的会议，致力于在全球范围内翻译中风治疗中的侧支循环的关键问题。尤其重要的是，将在年度国别调查的基础上介绍在中风中使用血流动力学的间歇性进展。专门为辩论、解决方案和早期职业与基础科学主持的海报会议、动手操作的神经血管设备研讨会和穿插的网络机会将加强这一新兴领域的合作倡议。与以往会议一样，电子海报、会议记录和其他出版物的迅速传播将加强这一独特和受人尊敬的年度专题讨论会的影响。已经为适当代表性作出了专门努力，以使妇女人数均等，招募任职人数偏低的少数群体和残疾人，最终使参与者的范围极为多样化。对当地代表性不足的少数民族的实习生奖励将显著增强本次会议的教育影响。可衡量的结果将量化这次研讨会对NINDS使命的影响，该使命旨在增强侧支知识并减少因中风而导致的神经疾病的负担。这一独特的专业论坛从世界各地最先进的场所延伸出来，强调抵押在巨大规模上的及时影响，鼓励最大限度地参与、快速传播和增加网络资源的价值。

PROJECT SUMMARY/ABSTRACT The 8th International Symposium on Collaterals to the Brain is a multidisciplinary scientific conference focused on collateral circulation in ischemic stroke. This proposal requests partial support for a conference with broad, long-term objectives that will advance current research on collateral blood flow and identify gaps in current treatment strategies around the world. The collaterome, or individual capacity to offset ischemia in the brain, and determination of a favorable collateral profile have become pivotal factors in the consideration of cerebral ischemia and the precision medicine of stroke driving individualized medical decision-making. The conference directly addresses the most pressing issues and gaps in optimally defining collateral status that limits the realization of stroke therapies around the world. Decisive challenges include generalizability of optimal triage and selection paradigms based on collateral status for definitive treatment of ischemic stroke, rapid dissemination of expert methods and transformative advances, and the urgent need to leverage networking opportunities for stroke education and science related to hemodynamics of collaterals to the brain. The aims of this conference will convene faculty from around the world to connect on-site participants at the state-of-the-art facility with remote audiences in more than 75 countries and regions. Detailed presentation topics have been arranged around themes relating to the basic science, translational, clinical research, routine clinical aspects, imaging, endovascular therapy, and systems of care issues of collaterals in the brain. The confirmed program of this 3-day conference is structured into 40-minute sessions devoted to key issues in translating the collaterome in stroke therapy across the globe. Of particular importance is the interval progress on the use of hemodynamics in stroke that will be presented based on the annual country-based surveys. The dedicated sessions for debates, solutions, and the early career and basic science moderated poster session, hands-on neurovascular device workshop and interspersed networking opportunities will enhance collaborative initiatives in this burgeoning field. Rapid dissemination of electronic posters, proceedings, and other publications, as in past meetings, will intensify the impact of this unique and esteemed annual Symposium. Dedicated efforts for appropriate representation have already been delineated to have parity in the numbers of women, recruit underrepresented minorities and persons with disabilities, culminating in an extremely diverse spectrum of participants. Trainee awards for underrepresented minorities from the local region will markedly enhance the educational impact of this meeting. Measurable outcomes will quantify the impact of this symposium on the NINDS mission to enhance knowledge of collaterals and reduce the burden of neurological disease due to stroke. This unique forum of expertise extending from a state-of-the-art venue across the world emphasizes the timely impact of collaterals on a monumental scale, encouraging maximal participation, rapid diffusion, and added value of networking resources.