Bruins in Genomics: Dental, Oral & Craniofacial Research Training Program (BIG DOC)

建议的R25-NIDCR研究教育在基因组学培训计划中的多样性行动计划(DAP) 是提供暑期基因组科学，医学和社会方面的研究经验，牙科，口腔和 20例大学生颅面区下一代序列分析 来自不同背景的学生，特别是来自种族和民族群体的学生在 生物医学研究，残疾人和弱势群体。 NGS已经给生物科学和生物医学研究带来了革命性的变化，并即将改变临床 练习一下。培养新一代多样化的生物和定量牙医科学家和 口腔健康研究人员挖掘这些海量的公共数据，以应对当前面临的挑战 公共卫生。数据科学已经改变了医学基因组学领域，并可能渗透到方方面面 通过牙科、口腔和牙科的个性化治疗决定，从风险管理到床边的牙科 头面部疾病。我们预计对拥有强大大数据分析技能的牙科研究人员的迫切需求， 特别强调基因组学。这一需要在量化的要求中得到进一步强调 生物科学研究生项目、DDS/博士项目(T32、T90/R90)、DDS毕业后的分析技能 住院医师/博士课程(K12)一直到牙科实践。 满足牙科、口腔和颅面科学领域对来自不同领域的研究人员和从业者的需求 背景凭借强大的数据科学技能，我们将在牙科、口腔和 颅面研究培训计划(BIG DOC)“。该计划将利用 现有的，非常成功的加州大学洛杉矶分校“Bruins-in-Genology(BIG)”夏季本科生研究项目(BIG 夏季)，由加州大学洛杉矶分校的定量和计算生物科学研究所(QCB)主办。大的 夏季课程包括侧重于NGS数据分析技能的实用研讨会教程，以及 与加州大学洛杉矶分校的教授在基因组科学、医学和社会方面的实践研究经验。建议数 R25-NIDCR BIG DOC计划将资助20名学生加入现有的大型暑期计划，并与 致力于牙科、口腔和颅面基因组学研究的教师。学生将是定量的或 生物科学专业的学生进入三年级和四年级。我们预计，对于我们的许多参与者来说，这 研究经验将作为他们牙科研究生涯和职业发展的起点， 口腔和颅面研究。项目招聘将强调学术卓越、热情和多样性 和代表不足的少数族裔。

The proposed R25-NIDCR Research Education in Genomics Training Program with Diversity Action Plan (DAP) is to provide summer research experience in Genomic Sciences, Medicine and Society in dental, oral and craniofacial areas with a special emphasis on analysis of next generation sequences (NGS) for 20 undergraduate students from diverse backgrounds, specifically students from racial and ethnic groups underrepresented in biomedical research, with disabilities, and from disadvantaged backgrounds. NGS has revolutionized biosciences and biomedical research and is on the verge of transforming clinical practice. It is critical to train a new and diverse generation of biological and quantitative dentist scientists and oral health researchers for mining this vast amount of public data in order to address current challenges to public health. Data science has transformed the field of medical genomics and is likely to permeate all aspects of dentistry from risk management to the bedside through personalized treatment decisions on dental, oral and craniofacial diseases. We anticipate a critical need for dental researchers with strong skills in big data analysis, with particular emphasis on genomics. This need is further emphasized in the requirements of quantitative analysis skills in biosciences graduate programs, DDS/PhD programs (T32, T90/R90), Post-DDS Residency/PhD program (K12) programs all the way to the practice of dentistry. To address the need in dental, oral and craniofacial science for researchers and practitioners from diverse backgrounds with strong data science skills, we will establish the “Bruins-In-Genomics in Dental, Oral and Craniofacial Research Training Program (BIG DOC)”. This program will leverage the infrastructure of the existing, highly successful UCLA “Bruins-In-Genomics (BIG)” Summer Undergraduate Research Program (BIG Summer)” which is hosted by the Institute for Quantitative and Computational Biosciences (QCB) at UCLA. BIG Summer consists of a combination of practical workshop tutorials that focus on NGS data analysis skills, and a hands-on research experience with UCLA faculty in genomic sciences, medicine and society. The proposed R25-NIDCR BIG DOC program will fund 20 students to join the existing BIG Summer program and partner with faculty with a research focus in dental, oral and craniofacial genomics. The students will be quantitative or biosciences majors entering their junior and senior years. We expect that for many of our participants, this research experience will serve as a launching point for their research careers and career development in dental, oral and craniofacial research. Program recruitment will emphasize academic excellence, enthusiasm, diversity and underrepresented minorities.