Population Studies and Disparities Research

人口研究和差异研究--摘要 人口研究和差异研究(PSDR)计划致力于确定关键的基因 和潜在疾病发生和发展的行为风险因素以及开发和测试新的 降低风险、改善诊断、治疗和结果的干预策略，重点是 减少和/或消除我们集水区内人口之间的癌症健康差距。 这个互动项目包括来自韦恩州立大学11个系和3所学校的28名成员 以及6936,093美元的同行审查，与癌症相关的资金，其中5,793,590美元来自NCI。PSDR 该计划有两个最重要的科学主题。第一个主题是调查分布和 在一个种族和民族多元化的人群中，癌症风险、存活率和结果的决定因素。主修 这一主题下的科学研究利用遗传学的新进展来解决我们高度多样化的 集水区大约25%的人口是非洲裔美国人，其中包括最大的阿拉伯裔美国人 美国社区；发展项目对象性和性别少数族裔癌症幸存者和农村 在我们扩大的集水区内的人口。这项工作是由底特律地区以人口为基础的 癌症登记处，SEER计划的创始参与者，这是一种被广泛利用的资源 肺癌、乳腺癌、前列腺癌、结肠癌、卵巢癌和子宫内膜癌的人群流行病学研究 在不同的人群中。第二个主题是开发和测试以证据为基础的干预措施，重点是 患者、家庭成员和医生的行为，以减少癌症预防、治疗、 生存和临终结局。这一主题的主要焦点是改变社会和行为因素 推动危险行为、筛查和治疗选择、医-患-家属素质 不同种族和种族的成人和儿童的沟通、症状管理和生存 人口。这项工作得到了独特的、定制设计的视频数据捕获系统的支持，该系统安装在多个 诊所网站，研究种族偏见和沟通不良如何导致不平等治疗决定和 健康结果。未来的方向包括发展以非裔美国人为重点的多元PI赠款 癌症幸存者，利用底特律癌症幸存者研究(底特律ROCS)队列研究。底特律 ROCS研究是专门在非洲裔美国人癌症幸存者中进行的最大规模的单一队列研究， 目标是了解这一人群中较差结果的决定因素。电子健康技术将增强 患者与提供者之间的沟通也在发展中。PSDR计划成员积极与 KCI的MI、MT和TBM项目的成员。在2015年12月出版的409篇稿件中 截至2019年11月，43%和25%分别是方案内和方案间，74%是多方案 机构合作。

POPULATION STUDIES AND DISPARITIES RESEARCH – ABSTRACT The Population Studies and Disparities Research (PSDR) Program is committed to identifying key genetic and behavioral risk factors underlying disease onset and progression and developing and testing novel intervention strategies to reduce risk and improve diagnosis, treatment, and outcomes with an emphasis on reducing and/or eliminating cancer health disparities among populations contained within our catchment area. This interactive Program includes 28 members from 11 departments and 3 schools at Wayne State University and $6,936,093 in peer reviewed, cancer-related funding, of which $5,793,590 is from the NCI. The PSDR Program has two overarching scientific themes. The first theme is to investigate the distribution and determinants of cancer risk, survivorship, and outcomes in a racially and ethnically diverse population. Major scientific investigations under this theme use emerging advances in genetics to address our highly-diverse catchment area population that is approximately 25% African American, includes the largest Arab-American community in the US; developing projects target both sexual and gender minority cancer survivors and rural populations within our expanded catchment area. The work is supported by the Detroit area population-based cancer registry, a founding participant in the SEER Program, a resource that is well-leveraged for extensive population-based studies of the epidemiology of lung, breast, prostate, colon, ovarian, and endometrial cancers in diverse populations. The second theme is to develop and test evidence-based interventions focused on patient, family member, and physician behaviors to reduce disparities in cancer prevention, treatment, survivorship, and end-of-life outcomes. The main focus of this theme is modifying social and behavioral factors driving risk behaviors, screening and treatment choices, the quality of physician-patient-family member communication, symptom management, and survivorship in racially and ethnically diverse adult and pediatric populations. The work is supported by a unique, custom-designed video data capture system installed in multiple clinic sites to study the ways racial bias and poor communication give rise to unequal treatment decisions and health outcomes. Future directions include the development of multi-PI grants focused on African American cancer survivors, leveraging the Detroit Research on Cancer Survivors (Detroit ROCS) cohort study. The Detroit ROCS study is the largest single cohort conducted exclusively among African American cancer survivors with a goal of understanding the determinants of poorer outcomes in this population. eHealth technologies to enhance patient-provider communication are also being developed. PSDR Program members actively collaborate with members of the MI, MT, and TBM Programs at KCI. Of the 409 manuscripts published from December 2015 to November 2019, 43% and 25% were intra- and inter-programmatic, respectively, and 74% were multi- institutional collaborations.