High-Density surface EMG based CMAP scan for motor unit number estimation

项目摘要 本研究旨在开发一种新的运动单位数估计(MUNE)技术，该技术将两种方法相结合 电生理学的最新进展，即复合肌肉动作电位(CMAP)扫描和高密度 表面肌电图(HDEMG)，以提供准确和可靠的估计功能的运动单位 肌肉。所提出的技术将被用作量化或跟踪运动单位的敏感生物标志物。 临床环境中的人群或探索轴突兴奋性和肌肉重排对 衰老、肌萎缩侧索硬化症(ALS)和其他神经系统疾病的药物、运动或物理治疗 精神错乱。

Project Abstract This research aims to develop a novel motor unit number estimation (MUNE) technique that integrates two recent advances in electrophysiology, i.e. compound muscle action potential (CMAP) scan and high-density surface electromyography (HDEMG), to provide accurate and reliable estimation of functioning motor units in the muscle. The proposed technique will be used as a sensitive biomarker for quantifying or tracking motor unit population in clinical settings or to explore axon excitability and muscle rearrangements in response to medication, exercises or physical therapies in aging, amyotrophic lateral sclerosis (ALS) and other neurological disorders.