The Mutant Mouse Resource and Research Center at the University of Missouri

项目概要-总体 突变小鼠资源和研究中心（MMRRC）是美国主要的突变小鼠档案馆 和分发库系统，其主要目标是通过识别，获取， 评估、表征、冷冻保存突变小鼠品系，并将其分配给合格的生物医学 investigators. MMRRC是由NIH建立的，以确保保存，传播， 开发有价值的突变小鼠品系和研究科学家产生的数据。MMRRC是一个 由四个中心组成的联盟，每个中心都有一个存档和分发库，以及一个信息学中心。 协调和服务中心（ICSC）在一个跨国家网络内， 美国的这些中心共同服务于国家生物医学研究界的需求， 确保获得和优化利用转基因、基因敲除和其他基因工程突变体 小鼠及相关生物材料、服务和新技术。这些中心进口、核实、维护和 分配小鼠，基因靶向胚胎干细胞（ES细胞），和遗传独特的种质，科学地 珍贵的老鼠中心还提供服务和程序，以协助研究人员使用转基因技术， 老鼠做研究最后，各中心开展与资源相关的研究，通常是合作进行， 开发突变小鼠品系，利用小鼠遗传学的力量进行生物医学研究。通过 将他们的突变小鼠存放在中心的储存库中，NIH资助的研究人员履行了他们的义务， NIH共享政策。作为回报，每个中心都努力保存，保护，质量控制，并提供 这些模型的研究科学家和调查人员在全国和地球仪的利益。做 因此，MMRRC确保有价值的突变小鼠品系在生物医学领域公平地可用。 研究社区，从而加快研究和发现的步伐，使用转基因小鼠。

PROJECT SUMMARY - OVERALL The Mutant Mouse Resource and Research Center (MMRRC) is the nation’s primary mutant mouse archive and distribution repository system, the primary goal of which is to facilitate research by identifying, acquiring, evaluating, characterizing, cryopreserving, and distributing mutant mouse strains to qualified biomedical investigators. The MMRRC was established by the NIH to ensure the preservation, dissemination, and development of valuable mutant mouse lines and data generated by research scientists. The MMRRC is a consortium of four Centers, each hosting an archive and distribution repository, and an Informatics Coordination and Service Center (ICSC) within a trans-national network regionally distributed across the United States. The Centers collectively serve the needs of the nation’s biomedical research community, ensuring access to and optimizing utilization of transgenic, knockout, and other genetically engineered mutant mice and related biomaterials, services, and new technologies. The Centers import, verify, maintain, and distribute mice, gene-targeted embryonic stem (ES) cells, and germplasm of genetically unique, scientifically valuable mice. Centers also provide services and procedures to assist investigators using genetically altered mice for research. Finally, Centers conduct resource-related research, often collaboratively, to further refine and develop mutant mouse lines and capitalize on the power of mouse genetics for biomedical research. By depositing their mutant mice in repositories at the Centers, NIH-funded investigators fulfill their obligation under the NIH Sharing Policy. In return, each of the Centers strives to preserve, protect, quality control, and provide these models for the benefit of research scientists and investigators across the nation and the globe. In doing so, the MMRRC ensures that valuable mutant mouse lines are available equitably across the biomedical research community, thereby accelerating the pace of research and discovery using genetically altered mice.