Center of Excellence in Environmental Toxicology

总体：摘要 这是第三个竞争延续完成环境健康科学核心中心（EHS CC），宾夕法尼亚大学（Penn）环境毒理学卓越中心（CEET）。 导演是特雷弗M。彭宁博士（The Thelma Brown and亨利查尔斯莫利诺夫教授， 药理学）和副主任是丽贝卡A。西蒙斯，医学博士（哈勒姆伤害捐赠教授， 儿科）。该中心由来自18个部门和5个学校的71名成员组成，几乎平等 来自佩雷尔曼医学院（PSOM）的基础科学家和临床科学家的代表， 费城儿童医院（CHOP）CEET建立了一个机构，区域和国家身份， 环境健康科学（EHS）在没有公共卫生学院和EHS系的情况下， 宾夕法尼亚州CEET内基础和临床科学家的协同组合促进了翻译 环境健康研究，解决基本问题，并将知识转化为行动， 对人类健康和疾病产生重大影响，符合NIEHS战略计划。CEET使命 阐明环境暴露与人类疾病之间的机械联系， 将研究结果转化为行动，以改善弱势群体的健康，以及地方、国家和 全球社区”。这一使命通过五个目标来完成。目标1：我们使用灵活的主题 区域结构进行转化环境卫生研究，以改善精确的公共卫生。我们 当前的主题是空气污染和肺部健康;环境暴露和癌症; 敏感性;和环境神经科学。每个主题领域都整合了支柱或接触科学， 不利的结果结构（途径和网络），以解释现象与翻译的社区 和人类实验对象。目标2：我们与东南部和东北部的社区进行双向沟通。 宾夕法尼亚州和使用社区参与设置CEET的研究议程。目标3：我们提供 设施核心结构，促进精准公共卫生。我们的综合健康科学设施核心是熟练的 在人类受试者研究设计和进行人口接触服务中，使用制图建模， GIS工具和生物传感器。暴露和效应的生物标志物在我们的翻译生物标志物核心中进行测量 其以难以在其它地方模仿的精确度和准确度水平进行质谱测定。 Exposure Biology Informatics Core带来了计算、机器学习和人工智能的力量， 预测未知因素的毒性，并整合大数据集，以识别"组学"数据中的模式， 不良后果。目标4：我们通过资助试点项目， 早期研究员（ESI）和高级研究员进行环境健康研究的第一个 时间目标5：我们通过变革性的环境健康科学家支持来培养ESI的职业生涯 该计划提供指导，赠款提案审查，环境健康和设施核心讲习班。

OVERALL : ABSTRACT This is the third competing continuation for an accomplished Environmental Health Sciences Core Center (EHS CC), The Center of Excellence in Environmental Toxicology (CEET) at the University of Pennsylvania (Penn). The Director is Trevor M. Penning, PhD (The Thelma Brown and Henry Charles Molinoff Professor of Pharmacology) and the Deputy Director is Rebecca A. Simmons, MD (The Hallam Hurt Endowed Professor in Pediatrics). The Center is comprised of 71 members from 18 Departments and 5 Schools, with almost equal representation of basic and clinician-scientists drawn from the Perelman School of Medicine (PSOM) and Children’s Hospital of Philadelphia (CHOP). The CEET has built an institutional, regional and national identity in environmental health sciences (EHS) in the absence of a School of Public Health and Department of EHS at Penn. The synergistic combination of basic and clinician-scientists within the CEET promotes translational environmental health research that addresses fundamental questions and translates knowledge into action to have a major impact on human health and disease consistent with the NIEHS Strategic Plan. The CEET mission is to “elucidate the mechanistic links between environmental exposures and human disease, and translate findings into action to improve the health of vulnerable individuals, and local, national, and global communities”. This mission is accomplished through five aims. In Aim 1: We use a flexible thematic area structure to conduct translational environmental health research to improve precision public health. Our current themes are in Air Pollution & Lung Health; Environmental Exposures & Cancer; Windows-of- Susceptibility; and Environmental Neuroscience. Each thematic area integrates the pillars or exposure science, adverse outcome constructs (pathways and networks) to explain the phenome with translation to communities and human subjects. In Aim 2: We conduct bi-directional communication with communities in S.E and N.E. Pennsylvania and use community engagement to set the research agenda for the CEET. In Aim 3: We provide a facility core structure to promote precision public health. Our Integrative Health Sciences Facility Core is adept in human subject study design and in conducting population exposure services, using cartographic modeling, GIS tools and biosensors. Biomarkers of exposure and effect are measured in our Translational Biomarker Core which conducts mass spectrometric assays at a level of precision and accuracy difficult to emulate elsewhere. The Exposure Biology Informatics Core brings to bear the power of computation, machine learning and AI to predict the toxicity of unknowns and integrate Big-data sets to recognize patterns in “omics” data and predict adverse outcomes. In Aim 4: We build capacity in environmental health sciences by funding pilot projects to Early Stage Investigators (ESI) and to senior investigators conducting environmental health research for the first time. In Aim 5: We cultivate the careers of ESI through a transformative Environmental Health Scientist Support Program that provides mentoring, grant proposal review, environmental health and Facility Core workshops.