Incorporation of a Hypertension Working Group into the Jackson Heart Study

根据最近的发现，2020年研究非洲裔美国成年人的高血压比以往任何时候都更重要 54%的非洲裔美国成年人患有高血压，只有19%的人的血压（BP）得到控制， 指南推荐水平，血压升高和高血压占心血管疾病的33% (CVD)非裔美国人之间的事件。2030年美国心脏协会（AHA）的影响目标是 在未来十年内，将美国成年人的健康调整预期寿命延长3年。适应健康的生活 与白色成年人相比，非洲裔美国人的预期寿命较短， 杰克逊心脏研究（JHS）表明，与没有心脏病的人相比， 高血压在本申请中，我们建议更新JHS高血压工作组（JHS- HWG），这将解决新的高优先级BP研究问题，在非洲裔美国人，也有助于 指导高血压研究的早期研究者（ESI）。鉴于其庞大的样本量和广泛的 表型，JHS是解决高血压中的几个知识缺口的理想设置， 非裔美国人2000年至2004年，5,306名非洲裔美国人参加了JHS，并完成了 基线研究访视，包括门诊血压测量和关于社会决定因素的问卷调查。 健康和健康行为。已经进行了三次研究访视，此时高血压发作， 评估器官损伤。参与者已被随访超过16年的CVD事件。过去 两个资助周期（7年），30个JHS-HWG ESIs，包括16个代表性不足的少数民族调查员， 发表了48篇稿件，其中6篇稿件正在接受同行评审。JHS-HWG ESI已成功 获得了赠款资助，包括四个R 01奖，七个职业发展奖（六个来自NIH，一个来自 来自AHA），三个多样性补充，和一个博士前F31奖。在下一个赠款周期，我们 建议在四个核心专题领域开展研究：（1）健康的社会决定因素和 高血压和血压控制;（2）健康行为和高血压和血压控制的风险;（3）比较 非裔美国人与非洲黑人高血压的研究;（4）高血压的影响 预防和BP控制对增加健康调整后的预期寿命具有重要意义。为环境服务机构举办的新培训活动 包括跨学科团队科学介绍、职业发展规划、基金撰写 讲习班、小组同侪辅导和写作问责小组。此外，我们将提供职业培训， 现在处于职业生涯中期的前JHS-HWG ESI。JHS-HWG将由主要研究人员领导，他们 强大的合作历史，以及发表高影响力高血压研究的既定记录 和指导紧急支援人员通过JHS-HWG，我们的目标是确定预防高血压的方法， BP控制和增加非裔美国人的健康调整预期寿命，同时提供创新的 为下一代高血压研究人员提供培训和职业发展机会。

Studying hypertension in African-American adults in 2020 is more important than ever in light of recent findings that 54% of African American adults have hypertension, only 19% have their blood pressure (BP) controlled to guideline recommended levels, and elevated BP and hypertension account for 33% of cardiovascular disease (CVD) events among African Americans. The 2030 American Heart Association (AHA) impact goal is to increase the health-adjusted life expectancy of US adults by 3 years over the next decade. Health-adjusted life expectancy is shorter in African Americans compared with white adults and our preliminary data from the Jackson Heart Study (JHS) indicates its 7 years shorter among African American adults with versus without hypertension. In this application, we propose the renewal of the JHS Hypertension Working Group (JHS– HWG), which will address new high priority BP research questions in African Americans and also serve to mentor early stage investigators (ESIs) in hypertension research. Given its large sample size and extensive phenotyping, the JHS is the ideal setting for addressing several knowledge gaps in hypertension among African Americans. Between 2000 and 2004, 5,306 African Americans were enrolled in the JHS and completed a baseline study visit that included clinic BP measurements and questionnaires on social determinants of health and health behaviors. Three study visits have been conducted at which time hypertension onset and organ damage were assessed. Participants have been followed over 16 years for CVD events. Over the past two funding cycles (7 years), 30 JHS-HWG ESIs, including 16 under-represented minority investigators, have published 48 manuscripts with 6 manuscripts undergoing peer review. JHS-HWG ESIs have successfully obtained grant funding including four R01 awards, seven career development awards (six from NIH and one from AHA), three diversity supplements, and one pre-doctoral F31 award. For the next grant cycle, we propose to conduct research in four core thematic areas: (1) social determinants of health and risk for hypertension and BP control; (2) health behaviors and risk for hypertension and BP control; (3) comparative research on hypertension in African Americans versus black Africans; and (4) the impact hypertension prevention and BP control has on increasing health adjusted life expectancy. New training activities for ESIs include an introduction to interdisciplinary team science, career development planning, grant writing workshops, group peer mentoring, and writing accountability groups. Also, we will provide career training for former JHS-HWG ESIs that are now mid-career. The JHS-HWG will be led by principal investigators, who have a strong collaborative history, and an established track record of publishing high impact hypertension research and mentoring ESIs. Through the JHS-HWG, we aim to identify approaches to prevent hypertension, improve BP control and increase health-adjusted life expectancy among African Americans while providing innovative training and career development opportunities for the next generation of hypertension researchers.