SUstainable nanoPaRticles Enabled antiMicrobial surfacE coatings (SUPREME)

正在进行的灾难性大流行吸引了我们对高交通表面促进有害病原体传播的关注，突显了在经济和环境上可持续的抗菌表面解决方案作为减缓疾病暴发传播的潜在战略的重要性和紧迫性。纳米颗粒(NP)填充涂层具有公认的抗细菌、病毒和真菌的有效性，是开发抗微生物表面和最大限度减少病原体表面粘附性的有价值的候选材料。然而，由于纳米涂层的许多技术挑战，包括难以开发出具有长期抗菌能力、实际条件下的耐久性和安全保证的纳米涂层，它们在工业层面的应用仍然受到限制。最高财团将开发一个高效、多功能的抗菌纳米涂料平台，建立在定制的二氧化钛纳米颗粒的基础上，这些纳米颗粒在实验室规模上表现出了非凡的抗菌能力(TRL3)。有两条可持续的路线：1)定制的核/壳和先进的功能纳米颗粒；2)混合纤维纳米颗粒(使用可持续的生物纤维素材料和纳米颗粒)。考虑到个别应用的具体要求，最高联盟将协调抗菌测试，以确保其对各种病原体的有效性。最高涂层的生产将遵循可持续的设计方法，从一开始就考虑到毒性和环境影响，以保证整个过程的市场接受度和可持续性，同时为人类健康提供强有力的安全保证。扩大这些可持续材料的生产并根据工业要求对其进行验证将使其能够在项目结束时达到TRL6。

The catastrophic ongoing pandemic has attracted our attention towards the spread of harmful pathogens facilitated by high traffic surfaces, highlighting the importance and urgency of an economically and environmentally sustainable solution for antimicrobial surface as a potential strategy to mitigate the spread of disease outbreaks. Nanoparticle (NP) filled coatings, with recognised effectiveness against bacteria, viruses, and fungi, are valuable candidatesfor developing antimicrobialsurface and minimising the surface adhesion of pathogens. However, due to the many technical challenges, including difficulty to develop nanocoatings with a long-term antimicrobial capability, durability under real conditions and safety assurance, their application at industrial level is still limited. The SUPREME consortium will develop a platform of efficient and multifunctional antimicrobial nanocoatings, building upon bespoke TiO2 nanoparticles that have demonstrated an exceptional antimicrobial ability at lab scale (TRL3). Two sustainable routes: 1) customised core/shell and advanced functional nanoparticles and 2) hybrid fibre-nanoparticles (using sustainable bio-based cellulose materials and nanoparticles) will be pursued. Bearing in mind the specific requirements of individual applications, the SUPREME consortium will coordinate the antimicrobial testings to its effectiveness against a wide range of pathogens. The production of the SUPREME coating will follow a sustainable-by-design approach that considers both toxicity and environmental impact from outset to guarantee both market acceptance and sustainability of the overall process whilst having a robust safety assurance in place for human health. The scaling-up production of these sustainable materials and their validation according to the industrial requirements will enable to reach the TRL6 by the end of the project.