Complexity: Innovations in Promoting Health through Team Science

项目总结/摘要 复杂慢性病（CCC）在世界范围内引起大量发病率和死亡率， 不成比例地影响弱势和低/中等收入地区。虽然许多CCC是可以预防的， 患者目前受益于疾病诊断和治疗的持续改善，CCC相关 发病率和死亡率仍然很高。由于与相互关联的固有复杂性， 影响健康结果的诱发因素，多方面的方法是确定未来的关键 干预措施，可以预防和管理CCC，并尽量减少/管理的短期和长期后遗症， 治疗和疾病本身。未来发现创新和有效的方法，以尽量减少CCC 负担取决于新兴研究人员从事团队科学的技能和意愿， 与单一学科方法相比，增加了成功的机会。此次T32竞争性更新 应用程序将准备护士科学家利用协作科学团队和网络时， 制定和测试干预措施，以在高度复杂的情况下改善健康。此应用程序构建 通过扩大团队科学领域的培训机会，加强对复杂性这一重要概念的认识。 因此，这个T32更新应用程序的目标，题为复杂性：促进健康的创新 通过团队科学（CHEETAh），是教育11名博士前学员成为创新的科学家， 将利用团队科学方法来促进患有（或有风险） CCC。本提案中概述的教学计划、研究培训和导师计划是 与我们目前成功的T32培训计划一致，但我们将扩大以前的三年培训 计划制定一个四年计划，以促进更多的团队科学培训。 具体来说，我们将培训护士科学家：1）调查个人，社会和 环境因素，影响健康的个人和人群的风险或诊断为 慢性疾病，为干预措施的设计和测试提供信息; 2）当 开发和测试创新的干预措施，以解决高度复杂的问题; 3）设计和测试 促进健康的创新方法，防止个人慢性病的发展 和高危人群的人口水平;以及4）设计和测试促进健康的创新方法 为慢性病患者提供服务，使他们能够在长期疾病中生活得更好。 培训计划分为四个支柱：课程工作，研究经验，指导， 专业社会化，包括领导和参与团队。学员将受益于 个性化的发展计划和跨学科的导师团队。促进团队科学是一个交叉- 国家卫生研究所（NIH）战略计划和国家护理研究所的主题 研究（NINR）优先促进跨学科研究，以推进症状科学。

Project Summary/Abstract Complex chronic conditions (CCCs) cause substantial morbidity and mortality worldwide and disproportionately affect disadvantaged and low/middle income regions. Although many CCCs are preventable, and patients currently benefit from ongoing improvements in disease diagnosis and treatment, CCC-associated morbidity and mortality remains substantial. Due to the inherent complexity associated with the inter-related predisposing factors that influence health outcomes, multi-faceted approaches are critical to identifying future interventions that can prevent and manage CCCs, and minimize/manage the short and long-term sequelae of treatment and the disease itself. Future discovery of innovative and impactful approaches to minimize CCC burden depends on the skill and willingness of emerging researchers to engage in team science, which offers enhanced opportunities for success compared to a single disciplinary approach. This T32 competitive renewal application will prepare nurse scientists to leverage collaborative science teams and networks when developing and testing interventions to improve health in the context of high complexity. This application builds on the important concept of complexity by expanding the training opportunities in the area of team science. Thus, the goal of this T32 renewal application, entitled Complexity: Innovations in Promoting Health through Team Science (CHEeTAh), is to educate 11 pre-doctoral trainees to become innovative scientists who will leverage team science approaches to promote health for individuals and populations with (or at risk for) CCCs. The pedagogic program, research training, and mentorship plans outlined in this proposal are consistent with our current successful T32 training program, but we will expand the previous three-year training plan to a four-year plan to facilitate more training in team science. Specifically, we will train nurse scientists to: 1) Investigate the complex array of personal, social, and environmental factors that influence the health of individuals and populations at risk for or diagnosed with chronic illness to inform the design and testing of interventions; 2) Integrate team science approaches when developing and testing innovative interventions to address highly complex problems; 3) Design and test innovative approaches to promote health which prevent the development of chronic conditions at the individual and population levels in those at higher risk; and 4) Design and test innovative approaches to promote health among those with chronic conditions to enable them to live well with chronic illness. The training program is organized in four pillars: course work, research experience, mentoring, and professional socialization, all inclusive of leading and participating in teams. Trainees will benefit from an individualized development plan and an interdisciplinary mentorship team. Promoting team science is a cross- cutting theme within the National Institute of Health (NIH) strategic plan and the National Institute of Nursing Research (NINR) priority to foster cross-disciplinary research to advance symptom science.