Viral Pathogenesis and Evolution Training Program (VPETP)

项目摘要/摘要 病毒感染和疾病仍然是一个主要的全球健康问题，因此，我们支持 培养训练有素的科学家，他们准备领导病毒传播和发病机制的研究。这个 弗雷德·哈钦森癌症研究中心(Fred Hutch)和华盛顿大学(UW)有着丰富的历史 在过去的五年里，我们还极大地扩展了我们在 病毒进化研究。十年前，我们创建了一个病毒致病培训计划，以提供 为在弗雷德·哈奇和威斯康星州大学实验室进行病毒致病研究的受训者提供伞形计划。 认识到研究病毒进化对更好地了解和预测病毒的重要性 流行病，我们建议在这里扩大我们计划的重点，包括病毒进化和计算 病毒研究-病毒致病和进化培训计划(VPETP)。因为博士前 追求病毒致病和进化研究的学生分散在不同的研究生中 在弗雷德·哈奇和威斯康星大学的计划和实验室，该计划对于创建具有凝聚力和 互动培训计划，将所有这些学生聚集在一起，提供更好的机会 那些由他们的特定研究生课程提供的课程。参加此培训计划的实验室研究 各种病毒感染，包括作为全球主要威胁的病毒，如DENV、埃博拉、艾滋病毒 流感、寨卡病毒以及致癌病毒(丙型肝炎病毒、KHSV、HPV、MCPyV)和机会主义(HSV、CMV、ADV) 病原体。参与实验室研究的病毒的多样性将增加该计划的广度，而 在所有参与的实验室中保持对病毒引起的疾病的总体关注。参加培训的学员 VPETP将从几个现有的研究生课程中挑选出来，这些研究生课程将病毒学培训作为 重点是。纳入使用计算方法研究病毒的实验室将提供 我们的学生有机会学习对下一代科学家至关重要的计算技能。 该培训计划的特点将包括常见的教学培训以及 学生和教职员工之间的演示和其他互动。这个共同的焦点将创造一个保护伞 对于接受这一培训资助的学生来说，这与现有的部门或课程结构不同。病毒式传播 致病和进化培训助学金是西雅图唯一一个专注于病毒研究的培训助学金 一般情况下，或病毒的发病机制和进化特别。

PROJECT SUMMARY/ABSTRACT Viral infection and disease continue to be a major global health issue and thus it is critical that we support the development of well-trained scientists who are poised to lead studies of viral spread and pathogenesis. The Fred Hutchinson Cancer Research Center (Fred Hutch) and University of Washington (UW) have a rich history of research in viral pathogenesis and over the past five years, we have also greatly expanded our expertise in viral evolution research. Ten years ago, we created a Viral Pathogenesis Training Program to provide an umbrella program for trainees pursuing research in viral pathogenesis in laboratories at Fred Hutch and UW. In recognition of the importance of studying the evolution of viruses to better understand and anticipate viral epidemics, we propose here to expand the focus of our program to include viral evolution and computational studies of viruses – the Viral Pathogenesis and Evolution Training Program (VPETP). Because predoctoral students pursing studies of viral pathogenesis and evolution are dispersed among a variety of graduate programs and laboratories at Fred Hutch and UW, this program is essential to create a cohesive and interactive training program that brings together all of these students to provide enhanced opportunities beyond those provided by their specific graduate program. The labs participating in this training program study a diverse array of viral infections, including viruses that are major global threats such as DENV, Ebola, HIV, Influenza, and Zika as well as oncogenic (HCV, KHSV, HPV, MCPyV) and opportunistic (HSV, CMV, AdV) pathogens. The diversity in the viruses studied among participating labs will add breadth to the program, while maintaining an overarching focus on virus-induced diseases among all the participating labs. Trainees for the VPETP will be drawn from several existing graduate programs that have training in virology as one area of emphasis. The inclusion of laboratories using computational approaches to the study of viruses will provide opportunities for our students to learn computational skills that are critical for the next generation of scientists. Features of this training program will include common didactic training as well as opportunities for presentations and other interactions among students and faculty. This common focus will create an umbrella for the students of this training grant that is distinct from existing departmental or program structures. The Viral Pathogenesis and Evolution Training Grant is the only training grant in Seattle that is focused on virus research in general or viral pathogenesis and evolution in particular.