UNMC Training Program in Alzheimer’s Disease and Related Dementias Drug Discovery

摘要 迫切需要建立一支专注于阿尔茨海默氏症的神经退行性疾病专家队伍 随着疾病的发展，生物医学研究界对多学科科学家的需求越来越大。 尽管有这种重要的需求，但很少有培训项目提供学术和临床方面的经验 设置。这项关于阿尔茨海默病和相关痴呆症药物发现培训计划的建议是 对于满足不断增长的需求至关重要。这个项目的总体目标是资助五名博士前学生。 从药学院和医学院成为跨学科研究的经验丰富的领导者 能够在具有广泛专业知识的跨学科团队中有效协作，以应对以下挑战 以靶向为基础的药物发现。该计划将帮助被选中的学生培养敏锐的科学严谨性和 在未来的工作中竞争并脱颖而出所需的翻译技能，包括但不限于学术能力 机构、政府机构、营利性企业和私人基金会。重要的是，该计划 教师来自广泛的学科，并有许多积极的合作。十二位导师致力于 参加这一培训计划的所有人，无论是终身教职还是终身教职，都有经验和资金来 承担他们的培训和指导角色。这些教师将为学员提供独特的计划，在其中 学习合作研究项目的技术和方法。拟议的培训计划是 包括正式的教学课程，以讨论为基础的期刊俱乐部和研讨会，临床医生的影子和 在进入研究生院的5.5年内指导研究，最终获得博士论文和博士学位。 这一创新计划将培养出一批具有高成就的学员，这些学员将在 TURN催化我们招募最优秀的学生参加这一跨学科的培训计划 内布拉斯加州医疗中心。

Abstract With a critical need to establish a workforce of specialists in neurodegenerative diseases focusing on Alzheimer’s disease, there is an increasing demand for multidisciplinary scientists in the biomedical research community. Despite this significant need, there are few training programs that provide experience in academic and clinical settings. This proposal for an Alzheimer’s Disease and Related-Dementia Drug Discovery training program is critical to meeting that increased demand. The overall goal of this program is to fund five predoctoral students from the Colleges of Pharmacy and Medicine to become experienced leaders in interdisciplinary research with the ability to collaborate effectively on cross-disciplinary teams with broad expertise to address challenges within target-based drug discovery. The program will help the selected students to develop keen scientific rigor and translational skills necessary to compete and excel in the future workplace, including but not limited to academic institutions, government agencies, for-profit businesses, and private foundations. Importantly, the program faculty are drawn from a wide array of disciplines with many active collaborations. Twelve mentors are dedicated to this training program, all either tenured or in tenure track positions, with the experience and funding to undertake their training and mentoring roles. These faculty will provide trainees with a unique program in which to learn techniques and methodologies of collaborative research projects. The proposed training program is composed of formal didactic courses, discussion-based journal clubs and seminars, shadowing of a clinician and mentored research leading to a doctoral thesis and Ph.D. degree within 5.5 years of entering graduate school. This innovative program will produce an outstanding output of trainees with high accomplishments that will in turn catalyze our recruitment of the best students for this interdisciplinary training program at the University of Nebraska Medical Center.