National Social Life and Aging Project: Wave 4

国家社会生活，健康和老龄化项目（NSHAP）是一项纵向研究， 扩展了我们对社会发展轨迹的机制的理解， 在人口老龄化中，连通性和健康相互交织。该项目是独一无二的， 在健康数据的广度和细节方面对老年人进行的全国代表性研究 收集，包括身体，心理，感官，功能，认知和社会 措施特别是，我们有无与伦比的结构变化的纵向措施， 的社交网络和关系的受访者及其合作伙伴在整个研究， 以及阿尔茨海默病和相关痴呆症（ADRD）的信息。我们建议 在2020-21年度（第4波[W 4]）与所有幸存的受访者及其 前三波（W1-W3）的配偶/伴侣，提供15年的随访和4年的随访。 这一重要队列（W 4时年龄为72-100岁）的数据波。对于W2中引入的创新- 多领域认知测量（MoCA-SA），详细的嗅觉评估，完整的 来自配偶/伴侣的数据，睡眠和日常活动的加速度计研究等 所有领域的综合测量-W 4将提供建模所需的第三个数据点 健康状况的变化、关联以及它们之间的因果关系。我们将加强 具有新认知指标的数据，包括项目响应时间、代理报告和 ADRD的诊断;链接到行政数据文件，如医疗保险;客观地 同时测量所有五种经典感官。作为一个例子，W 4将允许测试 关于从正常功能到痴呆的认知变化的关键假设， 对阿尔茨海默病的重要见解。 有了这些数据，我们的目标是扩大我们对机制的理解， 社会联系和健康的轨迹在人口老龄化中交织在一起。此外，本发明还 我们将制定一个框架，将最古老的NSHAP科目纳入内部和外部， 研究者发起的针对新的社会、行为和临床问题（如 神经退行性疾病，如阿尔茨海默病和相关痴呆）， 这一历史上未被充分研究的人群的样本。凭借其丰富而新颖的社会措施， 健康的生物、生理和心理组成部分-所有这些都是衡量 从两个合作伙伴在一对纵向NSHAP是唯一准备弥合差距 在社会关系和健康的大型流行病学研究和实验研究之间， 研究所涉及的机制。

The National Social Life, Health, and Aging Project (NSHAP) is a longitudinal study which extends our understanding of the mechanisms through which the trajectories of social connectivity and health are intertwined in an aging population. The project is unique among nationally representative studies of older adults in the breadth and detail of health data collected, incorporating physical, psychological, sensory, functional, cognitive and social measures. In particular, we have unparalleled longitudinal measures of changes in the structure of social networks and relationships of respondents and their partners throughout the study as well as information on Alzheimer's disease and related dementias (ADRDs). We propose to conduct in-home interviews in 2020–21 (Wave 4 [W4]) with all surviving respondents and their spouses/partners from the first three waves (W1-W3), providing 15 years of follow-up and four waves of data on this important cohort (aged 72-100 at W4). For innovations introduced in W2— a multi-domain measure of cognition (the MoCA-SA), detailed olfactory assessment, complete data from spouses/partners, an accelerometry study of sleep and daily activity, and more comprehensive measures in all domains—W4 will provide a third data point needed to model changes in health, associations, and causal relationships between them. We will enhance the data with new measures of cognition, including item response times, proxy reports, and diagnosis of ADRDs; linking to administrative data files, such as Medicare; and objectively measuring, concurrently, all five classic senses. As one example, W4 will allow the testing of key hypotheses regarding cognitive changes from normal function through dementia, providing important insights into Alzheimer's disease. With these data, we aim to extend our understanding of the mechanisms through which the trajectories of social connectivity and health are intertwined in an aging population. Additionally, we will develop a framework for enrolling the oldest NSHAP subjects into internal and external investigator initiated studies addressing novel social, behavioral, and clinical questions (such as neurodegenerative diseases like Alzheimer's disease and related dementias) in representative samples of this historically understudied population. With its rich and novel measures of social networks and of the biological, physical and psychological components of health—all measured longitudinally from both partners in a couple—NSHAP is uniquely poised to bridge the gap between large, epidemiological studies of social relationships and health and experimental studies of the mechanisms involved.