West Virginia Clinical and Translational Science Institute: Improving Health through Partnerships and Transformative Research

自新型冠状病毒（SARS-Cov-2）在美国出现以来， 确诊病例已达100万例，死亡人数已攀升至60多万人。的 机构发展奖励计划（IDEA）临床和转化研究中心 （CTR）位于美国的不同地区，为农村人口以及其他 服务不足的群体，包括美洲原住民，西班牙裔个人和有色人种。 由IDEA-CTR服务的许多州都是受COVID-19影响最严重的州之一 流行病国家COVID队列协作（N3 C）已由国家卫生部建立。 数据健康中心（CD 2 H）与国家推进中心合作 转化科学（NCATS）作为COVID研究的集中国家数据资源- 19.在过去的一年里，参加国家COVID队列协作的8名IDEA-CTR (N3C)提供了超过17.5万人的电子健康记录（EHR）数据 感染了SARS-COV-2。IDEA-CTR研究人员领导了多个N3 C领域团队， 参与了许多数据项目，并聘请了150多名IDEA州调查员， 美方此外，N3 C还刺激了IDEA CTR作为一种高度 协作网络。IDEA CTR现在已做好充分准备，可以在此经验的基础上实现 包括来自美国其他地区的EHR，扩大不同的参与， 整个IDEA州的调查人员，最重要的是，推动与少数民族相关的科学， 以及服务不足的IDeA州人口，并将结果传达给这些社区。我们 将通过以下目标实现这些广泛的目标：目标1 -构建IDEA-CTR 组织IDEA CTR之间协作的基础架构，以推动相关 科学; AIM 2 -扩展IDEA-CTR数据对N3 C的贡献，从而提高代表性 N3 C数据集中的少数民族、农村和其他服务不足的人口;目标3 -提供 必要的分析支持，使用一系列技术进行尖端的大数据研究， 包括机器学习（ML）和人工智能（AI），以回答重要的研究 关于SARS-CoV-2在IDEA州的影响的问题;以及目标4 -积极参与 IDEA的调查人员表示，他们可以开展高质量的COVID-19数据项目（通过 N3 C）与其各自州的人群相关，同时促进研究者的发展。

Since the emergence of the novel coronavirus (SARS-Cov-2) in the United States, more than 33 million cases have been confirmed, and the death toll has climbed to over 600,000 persons. The Institutional Development Award Program (IDeA) Clinical and Translational Research Centers (CTRs) are located in diverse areas of the US, serving rural populations as well as other underserved groups, including Native Americans, Hispanic individuals, and persons of color. Many states served by IDeA-CTRs have been among those hardest hit by the COVID-19 pandemic. The National COVID Cohort Collaborative (N3C) has been established by the National Center for Data to Health (CD2H) in partnership with the National Center for Advancing Translational Sciences (NCATS) as a centralized national data resource for the study of COVID- 19. Over the past year, the 8 IDeA-CTRs participating in National COVID Cohort Collaborative (N3C) have contributed electronic health record (EHR) data on more than 175,000 individuals infected with SARS-COV-2. IDeA-CTR investigators have led multiple N3C Domain Teams, participated in many data projects, and engaged more than 150 IDeA state investigators across the US. Moreover, N3C has served as a stimulus for the IDeA CTRs to work as a highly collaborative network. IDeA CTRs are now well poised to build on this experience to enable inclusion of EHRs from additional areas of the United States, broaden engagement of diverse investigators throughout IDeA states, and most importantly, to drive science relevant to minority and underserved IDeA state populations with communication of results to those communities. We will accomplish these broad objectives through the following aims: Aim 1 - Build IDeA-CTR infrastructure to organize collaboration among IDeA CTRs for purposes of driving relevant science; AIM 2 - Expand IDeA-CTR data contributions to N3C, thereby, increasing representation of minority, rural, and other underserved populations in the N3C dataset; Aim 3 - Provide the necessary analytic support to conduct cutting-edge big data research using a range of techniques, including machine learning (ML) and artificial intelligence (AI), to answer important research questions regarding impact of SARS-CoV-2 in IDeA states; and Aim 4 - Actively engage investigators in IDeA states to enable conduct of high quality COVID-19 data projects (through N3C) relevant to populations in their respective states while facilitating investigator development.