Training Program in Integrative Membrane Biology

项目摘要： 综合膜生物学培训计划（TPIMB）旨在培养博士前学生， 生物学、生物物理学和生物膜生理学。现在，在其第四个十年，TPIMB继续 在大学的分子，细胞和系统生物学的界面上领导跨学科培训的努力 马里兰州医学院（UMSOM）的研究，重点关注细胞膜和细胞内的作用 膜介导和整合细胞功能及其与环境的相互作用。的 该计划的指导思想是，膜生物物理学和生理学的研究，以及膜为基础的 信号级联，可以提供独特的见解细胞和组织的生物学，在健康和患病 states. TPIMB的教师人数为39人，资金充足，高度互动，并致力于 指导学生学习与膜生物学相关的广泛学科。导师的选择是为了 他们的兴趣，校外支持，并承诺辅导。学员是根据他们的兴趣挑选的， 研究生课程成绩，建议，和以前的研究经验。要求是核心课程 生物医学科学机制，以及为期一年的研究伦理学课程，两者都是 共同的所有实验室研究为基础的研究生教育在UMSOM。学员亦须参加 膜生物化学、生物物理学、膜与生物膜之间的联系等一系列专业高级课程， 缺陷和人类疾病，生物统计学，假设检验和实验设计。他们也可以采取 细胞和系统生理学、药理学或神经科学的选修课。学员定期参加 以学生为导向的活动，如学生研讨会系列，每月聚会和年度务虚会。的 UMSOM通过对教师工资的贡献慷慨地支持这一计划， 学生，并为TPIMB的定期活动提供资金。目前NIH/NIGMS资助7名受训人员，但 使许多学生在没有直接支持的情况下学习我们的课程并参加我们的活动。我们享受 与UMSOM的其他NIGMS支持的项目建立了强有力的伙伴关系，包括医学科学家 培训计划和迈耶霍夫研究生奖学金计划，一个国家认可的计划，支持 在科学领域代表性不足的少数民族。我们的研究生培养工作的力量，在 招聘，以及在UMSOM稳定的联邦资金表明，继续为我们的计划提供资金是好的 正当的在持续的支持下，TPIMB的教师和学生可以继续带头努力， 在UMSOM的膜，细胞和系统生物学的综合培训。

Project Summary: The Training Program in Integrative Membrane Biology (TPIMB) is designed to train pre-doctoral students in the biology, biophysics, and physiology of biological membranes. Now in its 4th decade, the TPIMB continues to lead the effort in interdisciplinary training at the interface of molecular, cell, and systems biology at the University of Maryland School of Medicine (UMSOM), by focusing on the role of the cell membrane and intracellular membranes in mediating and integrating the functions of cells and their interactions with the environment. The program is guided by the idea that studies of membrane biophysics and physiology, and of membrane-based signaling cascades, can provide unique insights into the biology of cells and tissues, in both healthy and diseased states. The faculty of the TPIMB, numbering 39 individuals, are well-funded, highly interactive, and devoted to mentoring students studying a broad range of subjects related to membrane biology. Mentors are selected for their interests, extramural support, and commitment to mentoring. Trainees are selected based on their interests, graduate course grades, recommendations, and previous research experience. Requirements are a core course on Mechanisms in Biomedical Sciences, as well as a year-long class in research ethics, both of which are common to all laboratory research-based graduate education at the UMSOM. Trainees are also required to take a series of specialized upper level courses in membrane biochemistry, biophysics, links between membrane defects and human diseases, biostatistics, hypothesis testing and experimental design. They may also take electives in cellular and systems physiology, pharmacology, or neuroscience. Trainees participate regularly in student-oriented activities, such as a student seminar series, monthly get-togethers, and an annual retreat. The UMSOM supports this program generously through contributions to faculty salary, additional stipends for students, and funds for the TPIMB's regular activities. Current NIH/NIGMS funding supports 7 trainees, but this leaves many students following our curriculum and taking part in our activities without direct support. We enjoy a strong partnership with other NIGMS-supported programs at the UMSOM including the Medical Scientist Training Program and Meyerhoff Graduate Fellows Program, a nationally recognized program that supports underrepresented minorities in the sciences. The strength of our graduate training efforts, successes in recruitment, and the stable federal funding at the UMSOM suggest that continued funding for our program is well justified. With continued support, the faculty and students in the TPIMB can continue to spearhead the effort to integrate training in membrane, cell and systems biology at the UMSOM.