Uncovering New Mechanisms of Metabolite-Sensing and Signaling

该项目旨在了解细胞如何感知代谢活动的变化，以确保能量需求与营养供应相匹配。我们的提议将填补我们对代谢传感的分子机制的理解中的关键空白。这将产生新的知识，对依赖生物繁殖和利用的澳大利亚工业，包括农业，生物技术和酿造业，以及与体育表现和衰老代谢方面有关的知识具有深远的潜力。该项目将支持早期职业研究人员和博士生的高级培训，这将扩大澳大利亚的研究能力，并有助于培养高技能的劳动力。

This project aims to understand how cells sense changes in metabolic activity, to ensure energy demands are matched with nutrient supply. Our proposal will fill critical gaps in our understanding of the molecular mechanisms underlying metabolic sensing. This will generate new knowledge with far reaching potential for Australian industries that rely on the propagation and utilization of living organisms, including agriculture, biotechnology and brewing, as well as knowledge relevant to sporting performance and the metabolic dimensions of ageing. This project will support advanced training of early career researchers and PhD students, which will expand Australian research capabilities and contribute to a producing a highly skilled workforce.