Autoimmunity and Immunopathology Training Program

这是请求恢复对匹兹堡大学医学院(UPSOM)培训的支持 自身免疫和免疫病理学(AI/IP)项目，目前资助4名博士后和4名博士后。 托拉实习生。人工智能/IP是一个中心的基础和应用研究领域，它正在带来基础免疫的洞察力。 以生物疗法和基于机制的疗法的形式向患者提供医疗服务。我们的AI/IP培训计划是这样的 与免疫学相关领域的其他(成功的)培训计划区分得非常清楚，例如在 传染病或移植，在皮特大学。我们已经取得了成功：在忠实地实施我们的导师的同时- 在计划中，我们已经或正在培训22名博士前学生，有20名不同的导师。十三个月前- 博士生已经完成了他们的博士学位，两个完成了他们的MD/博士学位。这些学生有 平均每篇发表论文5.8篇，第一作者论文平均2.5篇。我们的三位博士后 伙伴们都是乌姆。大多数人继续从事研究密集型职业，要么是博士后，要么是工业界。我们 已经培训或正在培训21名博士后研究员，有19名不同的导师，其中包括15名博士，3名博士 3名医学博士和博士。我们的博士后研究员中有三位是乌尔姆。我们的博士后实习生在 以基金会奖学金和K奖的形式获得进一步的资助。我们已经实施了一项新的 课程，自身免疫和免疫病理学，以及我们的“实习生日”活动提供双向 反馈。我们现在建议有意义地建立在现在经过验证的重要培训计划的基础上。 我们重点介绍了两个主要的改进：1)建立了一个新的研究生课程。微型机中的程序 生物与免疫学(PMI)成立于2017年，旨在加强重点免疫学和微生物学教育。 加强这些相关领域之间的联系。采购经理人指数的建立极大地促进了- 提高了申请者的质量和多样性，同时每年增加约6名学生。另外-- 由于投资和招聘，我们的免疫学教员已经扩大，我们的培训教员已经 从28增加到37。我们对博士前名额的竞争越来越激烈，我们正在 因此，本周期要求增加一个博士前空位；2)建立系统研究中心-- 市政学。该中心已经招聘了3名新教职员工，其中包括主任哈林德·辛格博士，并将 在这一关键新兴领域提供前沿研究和培训。我们的项目在支持下蓬勃发展- 生机勃勃，环境丰富。UPSOM深切关注培训，并实施了一系列有效的 确保在学生和博士后水平上进行出色培训的计划。申请者人数也是 杰出，鉴于我们成功的PMI和MSTP计划，我们备受欢迎的临床奖学金，以及 我们的导师池对直接申请的研究员的吸引力。我们很高兴能执行我们的培训计划 为即将到来的周期，并利用我们已经取得和已经取得的重大改进 在培训机会和师资方面都有计划。我们认为前景是不同寻常的。

This is a request for renewal of support for the University of Pittsburgh School of Medicine’s (UPSOM) training program in Autoimmunity and Immunopathology (AI/IP), which currently funds 4 predoctoral and 4 postdoc- toral trainees. AI/IP is a central basic and applied research area that is bringing the insights of basic immu- nology to patients in the form of biological and mechanism-based therapies. Our AI/IP training program is thus very clearly delineated from other (successful) training programs in immunology-related areas, such as in infectious disease or transplantation, at Pitt. We have had success: while faithfully implementing our mentor- ing plan, we have trained or are training 22 pre-doctoral students with 20 different mentors. Thirteen pre- doctoral students have completed their PhD and two completed their MD/PhD degrees. These students have published an average of 5.8 papers each, with an average of 2.5 first author papers. Three of our pre-doctoral fellows are URM. Most are continuing in research-intensive careers, either as postdocs or in industry. We have also trained or are training 21 post-doctoral fellows with 19 different mentors, including 15 PhDs, 3 MDs and 3 MD/PhDs. Three of our post-doctoral fellows are URM. Our postdoctoral trainees have had success in obtaining further funding in the form of Foundation fellowships and K awards. We have implemented a new course, Autoimmunity and Immunopathology, along with our “Trainee Day” activities that provide bidirectional feedback. We now propose to build meaningfully on what is now a proven and important training program. We highlight two major enhancements: 1) Establishment of a new graduate program. The Program in Micro- biology and Immunology (PMI) was created in 2017 to enhance focused Immunology and Microbiology edu- cation and to strengthen the links between these related areas. The establishment of PMI has greatly in- creased the quality and diversity of our applicant pool, while adding about 6 additional students/year. In addi- tion, due to investment and recruitment our Immunology faculty has expanded, and our training faculty has increased to 37 from 28. We have had increased high-quality competition for our predoctoral slots and are thus requesting an additional pre-doctoral slot for this cycle; 2) Establishment of the Center for Systems Im- munology. This Center has already recruited 3 new faculty including its director Dr. Harinder Singh, and will provide cutting edge research and training in this key emerging field. Our program flourishes within a support- ive and rich environment. UPSOM cares deeply about training and has implemented a series of effective programs to ensure outstanding training at the student and postdoc levels. The pool of applicants is also outstanding, given our successful PMI and MSTP programs, our highly sought-after clinical fellowships, and the attractiveness of our mentor pool for fellows applying directly. We are excited to execute our training plan for the upcoming cycle, and to capitalize on the significant improvements that we have made and have planned both for training opportunities as well as in terms of faculty. We feel that the prospects are exceptional.