Gestational Diabetes Mellitus, Perinatal Depression, and Offspring Neurodevelopmental Phenotype

项目总结 此K99应用程序旨在确定妊娠期糖尿病(GDM)和产前 产后抑郁对产妇心理健康、新生儿脑功能和幼儿脑行为的影响 发展。妊娠期糖尿病和抑郁症之间存在双向关联，它们影响大约 在美国分别有10%和13%的女性，而且不成比例地影响来自少数民族和 少数族裔群体。这两种情况都与神经发育不良独立相关。 对后代的结果包括增加社交、情绪和注意力缺陷的风险。尽管

PROJECT SUMMARY This K99 application aims to determine pathways by which gestational diabetes mellitus (GDM) and prenatal depression affect postpartum maternal mental health, neonatal brain function, and toddler brain-behavioral development. There is a bidirectional association between GDM and depression which affect approximately 10% and 13% of women in the United States respectively and disproportionately affect women from ethnic and racial minority groups. Both conditions are independently associated with adverse neurodevelopmental outcomes in offspring including increased risk for social-emotional and attentional deficits. Despite the