Boston University CCCR

整体 摘要 波士顿大学CCCR将作为临床研究的中心资源，主要集中在最 常见的肌肉骨骼疾病，骨关节炎和痛风，并将提供研究资源， 硬皮病、脊椎关节炎、肌肉骨骼疼痛和骨质疏松症的研究者基础研究。中心 赠款基金每年在同行评审的期刊上支持30-35篇论文，大多数是关于关节炎的。 期刊和一些领先的一般医学期刊。该中心培养了许多领先的临床 美国和国际上的风湿病学研究人员，这些前学员中有许多人 与中心积极合作。 我们将包括一个广泛的研究社区和教师的核心小组在这个CCCR。研究界的 随时获得核心教师和先进的研究方法和他们提供的援助将提高 社区的临床和转化研究，并将增加核心的合作机会 教师和社区。CCCR更新了BU对流行病学方法的历史关注， 因果推理的方法，并增加了机器学习和移动的健康的新方法。 研究和评价支助核心股是该CCCR的协调中心。一个关键特性是 每周研究（RESCU会议，其中正在进行的和拟议的研究项目进行批判性评估。 这一功能确保了临床研究人员、流行病学家和生物统计学家之间的频繁互动 他们是CCCR的核心成员。该中心的核心单位为其他中心提供了重要支持。 与波士顿大学风湿性关节炎疾病相关的赠款，目前有三个R 01/U 01;五个NIH K奖（1个K24、3个K23、1个K 01）、1个R 03、1个NIH试验计划补助金（U34）和多个ACR RRF奖。 该中心的总体目标是开展和传播高水平的临床研究， 本领域临床研究方法以及临床和生物科学发现。最终，我们的目标是 来预防我们正在研究的疾病，或者改善疾病患者的生活。

OVERALL ABSTRACT The Boston University CCCR will serve as a central resource for clinical research focused mostly on the most common musculoskeletal disorders, osteoarthritis and gout and will also provide research resources for investigator based research in scleroderma, spondyloarthritis, musculoskeletal pain and osteoporosis. Center grant funding has supported 30-35 papers annually in peer reviewed journals, most in the leading arthritis journals and some in leading general medical journals. This center has trained many of the leading clinical researchers in rheumatology throughout the US and internationally, and many of these former trainees have active collaborations with the center. We will include a broad research community and a core group of faculty in this CCCR. The research community's ready access to core faculty and to the sophisticated research methods and assistance they provide will enhance the clinical and translational research of the community and will increase collaborative opportunities for the core faculty and the community. The CCCR updates BU's historical focus on epidemiologic methods to include new approaches to causal inference and adds new methods in machine learning and mobile health. The Research and Evaluation Support Core Unit (RESCU) is the focal point of this CCCR. A key feature is the weekly research (RESCU meetings in which ongoing and proposed research projects are critically evaluated. This feature ensures frequent interactions between clinician researchers, epidemiologists and biostatisticians who are the core members of the CCCR. The RESCU core unit has provided critical support for other Center grants related to rheumatic and arthritic disorders at Boston University, three current R01/U01's; five current NIH K awards (one K24, 3 K23's, one K01), an R03, an NIH trial planning grant (U34), and multiple ACR RRF awards. The overall goal of this center is to carry out and disseminate high-level clinical research informed both by state of the art clinical research methods and by clinical and biological scientific discoveries. Ultimately, we aim either to prevent the diseases we are studying or to improve the lives of those living with the diseases.