Development of Sensitive and Specific Proteomic Biomarkers of Aging, Health, Frailty, and Morbidity in Human Cohorts

在这项研究合作的第一年，我们与Luigi Ferrucci博士和Toshiko Tanaka博士的早期工作表明，只需测量巴尔的摩老龄化和Inchianti老龄化队列的血液中的一组蛋白质，就可以预测生物年龄、虚弱和死亡率。发表在eLife和PLOS Biology上的这些结果表明，血浆中的蛋白质代表了基本的衰老过程，如细胞衰老，并且衰老相关蛋白质生物标志物的子集可以预测死亡率和共病。 未来这一研究项目的目的和范围是开发和应用基于最先进的质谱学的蛋白质组学技术，以发现和验证代表人体组织、血液和其他生物体液中衰老和疾病负担的蛋白质和蛋白质形式的子集。

Our early work in the first year of this research collaboration with Drs. Luigi Ferrucci and Toshiko Tanaka has demonstrated that biological age, frailty, and mortality can be predicted simply by measuring a panel of proteins in the blood from the Baltimore Longitudinal Study of Aging and InCHIANTI aging cohorts. These results, published in Elife and PLOS Biology, demonstrated that proteins in the plasma are representative of basic aging processes such as cellular senescence, and that a subset of senescence-associated protein biomarkers are predictive of mortality and co-morbidities. The purpose and scope of this research project going forward is to develop and apply state-of-the-art mass spectrometry based proteomic techniques to discover and validate subsets of proteins and protein forms that are representative of aging and disease burdens in human tissues, blood, and other biofluids.