CNS Mechanisms Linking Exercise Training with Energy Balance and Metabolism

摘要 我们已经组建了一个多学科的研究团队来调查大脑和关键外周是如何 代谢信号调节运动后的摄食和葡萄糖动态平衡。特别是，我们有 开发了一个项目，重点是使用独特的、遗传的老鼠模型来理解为什么运动训练 改善多种代谢参数，包括胰岛素敏感性和身体成分的变化。我们 提出一组项目，这些项目围绕着这样一个假设：其中几个与运动相关的影响 是通过大脑关键回路的变化来调节的。参与这一申请的调查人员，Elmquist，Betley 齐格曼和威廉姆斯将独特和协同的专业知识带到了谈判桌上。Elmquist/Betley组合将 探讨下丘脑腹内侧核(VMH)神经元在代谢调节中的作用 运动引起的变化。Zigman小组将研究Ghrelin的生理重要性 在调节运动反应中的信号传递。威廉姆斯小组将调查基本面的变化 三种紧密交织的运动训练后下丘脑神经元的细胞特性 将涉及外周组织和关键组织之间器官间通信的一些新方面 大脑中的区域。三个核心将支持这些努力中的三个项目：a)行政核心；b) 小鼠运动与代谢表型核心及C)神经解剖学/组织学/脑注射 核心。总而言之，这些创新和协同的研究将增加对如何锻炼的理解 训练通过改变中枢神经系统回路来调节关键的外周代谢信号。

ABSTRACT We have assembled a multidisciplinary team of investigators to investigate how the brain and key peripheral metabolic signals regulate feeding and glucose homeostasis following exercise. In particular, we have developed a program focused on using unique, genetic mouse models to understand why exercise training improves multiple metabolic parameters including insulin sensitivity and changes in body composition. We propose a set of projects that revolve around the hypothesis that several of these exercise-associated effects are mediated by changes in key brain circuits. The investigators involved in this application, Elmquist, Betley Zigman, and Williams bring distinct and synergistic expertise to the table. The Elmquist/Betley group will investigate the role of the ventromedial hypothalamus nucleus (VMH) neurons in the regulation of metabolic changes induced by exercise. The Zigman group will investigate the physiological importance of ghrelin signaling in regulating responses to exercise. The Williams group will investigate the changes in fundamental cellular properties of hypothalamic neurons following exercise training These three tightly interwoven Projects will address a number of new aspects of inter-organ communication between the peripheral tissues and critical regions in the brain. Three Cores will support the three Projects in these efforts: A) Administrative Core; B) Mouse Exercise and Metabolic Phenotyping Core and the C) Neuroanatomy/Histology/Brain Injection Core. In summary, these innovative and synergistic studies will increase the understanding of how exercise training regulates key peripheral metabolic signals via changes in central nervous system circuits.