Retinoic acid synthesis induced by noncoding dsRNA controls Regeneration

项目摘要摘要 这项拟议中的研究的长期目标是了解是什么控制了创伤是否会愈合 瘢痕形成/纤维化与完全再生丢失的结构。纤维化和疤痕造成的人类健康负担是 巨大，影响从心脏(心肌梗死后丧失心脏功能)到肺的每一个组织 (特发性肺纤维化)。例如，加强再生可以防止几乎普遍的癌症复发 在他们之前出现的确切位置上的慢性伤口。我们用伤口诱导的毛发 新生(WIHN)模型系统，其中在小鼠切除伤口的中心 再生发生并形成新生毛囊，这是胚胎发生的重演。这笔赠款的目的是 就是了解控制再生频率的因素。我们将直接测试这个机制 以及促进小鼠和人类受试者再生的候选分子的能力。结果是 这笔赠款承诺帮助确定新的治疗方法和诊断方法，以促进再生和伤口 治愈。

Project Summary Abstract The long term objective of the proposed research is to learn what controls whether injuries heal with scarring/fibrosis versus full regeneration of lost structures. The human health burden of fibrosis and scarring is enormous and affects every tissue from heart (lost heart function after a myocardial infarction) to lung (idiopathic lung fibrosis). Enhancing regeneration could prevent for example the almost universal recurrence of chronic wounds in the exact location where they previously appeared. We use the Wound Induced Hair Neogenesis (WIHN) model system where in the center of excisional wounds in mice a variable amount of regeneration occurs and de novo hair follicles form in a recapitulation of embryogenesis. The goal of this grant is to understand the factors which control the frequency of regeneration. We will directly test the mechanism and the ability for candidate molecules which enhance regeneration in mice and in human subjects. The results of this grant promise to help define new treatments and diagnostics to enhance regeneration and wound healing.