CORE D: BIC Core

总结/摘要 脑成像核心 该神经变性和转化神经科学中心（CNTN）COBRE第2阶段申请寻求 COBRE第一阶段资金继续取得成功，并要求建立一个 脑成像核心（BIC）。BIC的主要目标是扩展和改进成像和分析数据 分析方法，这将增加第二阶段项目的成功，产生新的试点项目， 与内华达大学拉斯维加斯分校（UNLV）和其他机构的研究人员建立合作关系 发展奖（IDEA）是对神经影像学感兴趣的社区。BIC的成功互动 与其他核心（数据管理和统计核心[DMSC]，临床和转化神经科学 核心[CTNC]）和II期初级研究者（JI）提供晋升为独立研究者的机会 研究事业，在内华达州建立神经科学基础设施，并促进对阿尔茨海默氏症的理解 帕金森病（PD）。专家成像和分析能力对于支持 研究和培训，并为BIC过渡到自我维持的核心奠定基础。主要 BIC的目标是为神经影像学研究中的JIs提供支持，并进一步描述患者的特征， 认知正常对照使用成像和分析数据分析。此外，BIC将开发教程 用于成像和数据分析方法的培训，并将提出新的方法，以更好地表征患者 神经退行性疾病导致改善的评估、诊断、分类和预测 准确性，以及翻译发现的工具。成像和数据分析方法将 所有COBRE项目的分析方法和培训的可用性将提供重要的 支持整个COBRE系统的JIs和其他研究人员。大脑和大脑之间的强大互动 一个成像小组将包括BIC和第一阶段的合作者，该小组将支持创建这个新的核心， CNTN。

SUMMARY/ABSTRACT Brain Imaging Core This Center for Neurodegeneration and Translational Neuroscience (CNTN) COBRE Phase 2 application seeks the continuation of success achieved with the COBRE Phase 1 funding and includes a request to establish a Brain Imaging Core (BIC). The primary goals of the BIC are to expand and improve imaging and analytic data analyses methods, which will increase the success of the Phase 2 projects, generate new pilot projects, and establish collaborations with researchers from University of Nevada-Las Vegas (UNLV) and other Institutional Development Award (IDeA) state communities with interests in neuroimaging. Successful interaction of the BIC with the other Cores (Data Management and Statistic Core [DMSC], Clinical and Translational Neuroscience Core [CTNC]) and Phase 2 Junior Investigators (JIs) provides opportunity for advancement to independent research careers, build neuroscience infrastructure in Nevada, and advances the understanding of Alzheimer’s disease (AD) and Parkinson’s disease (PD). Expert imaging and analytic capability is essential for supporting research and training and provides a foundation for transition of the BIC to a self-sustaining core. The major goals of the BIC are to provide support for JIs in neuroimaging research and to further characterize patients and cognitively normal controls using imaging and analytic data analyses. Furthermore, the BIC will develop tutorials for training on imaging and data analysis methods and will advance novel methods to better characterize patients with neurodegenerative disorders resulting in improved assessment, diagnosis, classification, and prediction accuracies, as well as tools for translational discovery. Imaging and data analysis approaches will be strengthened for all COBRE projects and the availability of analytical methods and training will provide significant support to JIs and other researchers throughout the COBRE system. Robust interactions between the brain imaging group that will comprise the BIC and collaborators in Phase 1 supports the creation of this new core in the CNTN.