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Anakinra for neutrophilic pustular skin disease

Anakinra for neutrophilic pustular skin disease
阿那白滞素（Anakinra）治疗中性粒细胞性脓疱性皮肤病
批准号：
10486881
负责人：
Edward Cowen
金额：
$9.64万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10486881
关键词：
BiologicalBiological MarkersClinicalClinical TrialsCollaborationsDataDiseaseDoseGeneralized pustular psoriasisGeneticImageInflammatoryInterleukin-1LaboratoriesManuscriptsPathway interactionsPatient Outcomes AssessmentsPatientsProtocols documentationPublicationsPustular psoriasisTherapeuticanakinraclinical outcome measuresdesignefficacy evaluationneutrophilnovelrecruitskin disordervascular inflammation

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中文摘要
翻译
该议定书不对招聘开放，将于2021年7月提交公布。本文总结了临床试验结果、基因数据、组织病理学相关性、全身炎症生物标记物、血管炎症成像、患者报告的结果以及试验中采用的新的临床结果指标。简而言之，Anakinra在局部和泛发性脓疱性牛皮癣中都显示出了疗效，方法是通过剂量递增的方法，每天sc最多3 mg。
英文摘要
This protocol is closed to recruitment and will be submitted for publication in July 2021. The manuscript summarizes the clinical trial results, genetic data, histopathologic correlaton, systemic inflammatory biomarkers, vascular inflammation imaging, patient reported outcomes and novel clinical outcome measures that were employed in the trial. Briefly, anakinra showed efficacy in both local and generalized pustular psoriasis in a dose escalation approach using dosing of anakinra of up to 3mg sc daily.
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Anakinra for neutrophilic pustular skin disease
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