Biostatistics and Bioinformatics Shared Resource (BBSR)

生物统计学与生物信息学 生物统计学和生物信息学共享资源（BBSR）的目标是确保优秀和及时的 以具有成本效益的方式为亚利桑那州癌症大学的所有研究项目提供协作支持 中心（UACC）。2020年，生物信息学服务与现有的生物统计学共享 为UACC研究人员提供一个有凝聚力的团队，以实现高水平的统计严谨性， 在他们的研究中创新。这一整合是对共享资源进行外部特别审查的结果 在2020年进行。在许多动物研究和临床试验都涉及药物的时代，这一变化至关重要。 收集“omics数据。在这种新的结构下，BBSR提供了高效的设计，准确的数据， 管理、定制数据分析和解释以及统计和生物信息学 创新，以确保UACC研究人员实现他们的科学目标。这种支持是由长期的支持- 在所有三个UACC研究计划和校园范围的数据BBSR人员的长期协调 科学倡议。BBSR的教职员工共同参与了概念，设计， 实施、分析和报告实验室、基因组、临床和基于人群的研究 在UACC内部进行。BBSR提供以下服务：（1）综合生物统计和 资助申请的生物信息学分析计划;（2）用户的生物统计学和生物信息学分析; 生成和公开可用的数据;（3）监测临床研究进展;（4）数据和软件 管理;（5）临床方案制定，包括样本量依据;（6） 通过在科学审查委员会（SRC）的服务执行UACC方案;（7）监测研究安全性， 通过在数据和安全监测委员会的服务确保数据完整性;以及（8）教育和培训， 临床研究员、学生和UACC成员。在CY 20，BBSR为35个UACC成员提供了统计数据， 为10项UACC加速器启动的试验提供方案开发支持，并为63项试验提供统计审查 SRC协议。在项目期间，BBSR支持了UACC成员的97份出版物 以及203份同行评审的资助申请。

BIOSTATISTICS & BIOINFORMATICS: ABSTRACT The goal of the Biostatistics & Bioinformatics Shared Resource (BBSR) is to ensure excellent and timely collaborative support in a cost-effective manner for all Research Programs of the University of Arizona Cancer Center (UACC). In 2020, bioinformatics services were combined with the existing Biostatistics Shared Resource to provide UACC investigators with one cohesive team to achieve a high level of statistical rigor and innovation in their research. This integration was a result of an external ad hoc review of Shared Resources conducted in 2020. This change is critical in an era when many animal studies and clinical trials involve the collection of ‘omics data. Under this new structure, BBSR provides efficient design, accurate data management, and customized data analyses and interpretation, as well as statistical and bioinformatics innovations, to ensure UACC investigators achieve their scientific goals. This support is facilitated by the long- term coordination of BBSR personnel across all three UACC Research Programs and campus-wide data science initiatives. BBSR faculty and staff are collaboratively involved in the conception, design, implementation, analysis, and reporting of laboratory, genomic, clinical, and population-based research conducted within the UACC. BBSR provides the following services: (1) integrated biostatistical and bioinformatics analysis planning for grant applications; (2) biostatistical and bioinformatics analysis of user- generated and publicly available data; (3) monitoring of clinical study progress; (4) data and software management; (5) clinical protocol development including sample size justification; (6) statistical review of UACC protocols through service on the Scientific Review Committee (SRC); (7) monitoring study safety and data integrity through service on the Data and Safety Monitoring Board; and (8) education and training for clinical fellows, students, and UACC Members. In CY20, BBSR served 35 UACC Members, provided statistical protocol development support for 10 UACC investigator-initiated trials, and provided statistical reviews for 63 SRC protocols. Over the course of the project period, BBSR has supported 97 publications by UACC Members and 203 peer-reviewed funding applications.