Enhancing functional capacity in older adults with short session high intensity interval training

短时间大强度间歇训练提高老年人功能能力的研究 虚弱是一种生理储备不足的状况，会增加跌倒的易感性， 住院、残疾和死亡率。虚弱的发生率在65岁以后迅速增加， 在85岁或以上的人中，从10%增长到50%；因此，超过900万退伍军人 虚弱的或者处于虚弱的危险中的运动已被证明对虚弱有好处，但老年人很少能达到 建议每周进行150分钟的中等强度运动。高强度间歇训练(HIIT) 正在成为一种替代选择，因为它在更少的时间内提供了与中等强度运动相似或更好的收益 时间到了。最近，我们发表了一篇文章，在老年小鼠身上进行每周3天、10分钟的HIIT疗法，不仅可以减少 脆弱，但会带来力量和耐力两方面的好处。此外，我们的初步数据表明， MicroRNA(MiRNA)图谱的显著变化。尽管短时间的HIIT有可能 提升功能能力，带来更好的 依从性，该医疗设备尚未经过测试 65-85岁的个人，以及 特别的、脆弱的个体。这样做的目的是 建议是：1)调查……的可行性 招聘和管理短期会议 他是虚弱的、前期虚弱的和非虚弱的老年人 退伍军人和2)描述体能 性能优势和血清microRNA 这些参与者的(MiRNA)图谱。 为了实现我们的目标，我们将实施一个总共只有10个人的短期HIIT养生法- 对65-85岁的参与者进行为期3个月的每周3天、每周3分钟的卧式锻炼。 我们还将利用下一代RNA序列技术来评估HIIT对microRNA的影响 血清样本中的特征。我们预计我们的项目将展示管理的可行性 向老年人，包括脆弱和体弱前期人群以及 展示收集和分析血清miRNA图谱的能力。这项计划的优点是 是保持或增加肌肉质量和改善有氧调节的能力，特别是在老年人 HIIT提高身体性能，降低脆弱性 在衰老过程中。 虚弱和骨质疏松症非常普遍的患者。因此，这一试点项目将为 未来的临床试验，进一步探索HIIT预防或延缓衰老的作用 更大的队列，并最终导致我们的功能能力和生活质量的增强 退伍军人人口老龄化。

Enhancing functional capacity in older adults with short session high intensity interval training Frailty is a condition of poor physiological reserve that increases susceptibility to falls, hospitalization, disability and mortality. The incidence of frailty rapidly increases after the age 65, growing from 10% to as many as 50% of those 85 years or older; therefore over 9 million veterans are either frail or at risk for frailty. Exercise has proven benefits for frailty, yet older adults rarely attain the recommended 150 minutes a week of moderate intensity exercise. High intensity interval training (HIIT) is emerging as an alternative as it delivers similar or better gains than moderate intensity exercise in less time. Recently, we published that a 3-day-a-week, 10-minute HIIT regimen in aged mice not only reduces frailty, but leads to both strength and endurance benefits. In addition, our preliminary data demonstrate significant changes in microRNA (miRNA) profiles. Despite the potential of short session HIIT to improve functional capacity and lead to better adherence, the modality has not been tested in individuals 65-85 years of age, and in particular, frail individuals. The goals of this proposal are to: 1) investigate the feasibility of recruiting and administering short session HIIT to frail, pre-frail, and non-frail older veterans and 2) to characterize the physical performance benefits and serum microRNA (miRNA) profiles in those participants. To accomplish our goals we will administer a short session HIIT regimen totaling only 10- minutes, 3-days-a-week for 3 months, using recumbent exercise cycles, to 65-85 year-old participants. We will also utilize next generation RNA-sequence technology to assess HIIT impacts upon microRNA profiles in serum samples. We anticipate our project will demonstrate the feasibility of administering short session HIIT to older individuals, including vulnerable frail and pre-frail populations as well as demonstrate the ability to collect and analyze serum miRNA profiles. The advantages to this program are the ability to maintain or build muscle mass and improve aerobic conditioning, especially in older HIIT enhances physical performance and reduces frailty during aging. patients where frailty and sarcopenia are so prevalent. This pilot project will therefore lay the foundation for future clinical trials that further explore the utility of HIIT to prevent or delay the onset of frailty in larger cohorts, and ultimately lead to the enhancement of functional capacity and quality of life in our aging veteran populations.