Oklahoma Center for Microbial Pathogenesis and Immunity

摘要 这个第一阶段Cobre计划的目标是发展和加强研究 基础设施、指导和协作环境，以支持五名初级调查人员 微生物发病机制和免疫学的多学科领域。为了实现这一目标， 俄克拉荷马州微生物致病和免疫中心(OCMP&I)科布雷将 建立和培育卓越中心，专注于促进青少年的职业生涯 研究人员研究威胁生命的感染微生物和免疫的方式 系统会对感染做出反应。OCMP&I Cobre将位于加州大学的中心位置 俄克拉何马州健康科学中心，美国生物医学研究的旗舰学术机构 俄克拉荷马州。OCMP&I Cobre最初将包括17名从事微生物研究的科学家 俄克拉荷马州研究密集型机构的发病机制和免疫研究 随着中心的形成和发展，网络将在第一阶段期间进行扩展。 在这17名科学家中，有5名杰出而有前途的初级调查人员，他们研究 真菌的发病机制、炎症、生物被膜的调节和坏死性小肠结肠炎。这个 OCMP&I及其由成功的高级研究员科学家组成的财团将提供 智力投入和专业知识，指导每一位初级研究人员独立研究。在……里面 除了出色的指导外，OCMP&I Cobre还将提供资金和研究 初级调查人员成功并成为长期贡献者所需的核心支持 俄克拉荷马州微生物致病机制和免疫研究社区。与…交织在一起 初级调查员支持，将是OCMP和I Cobre的使命，以解决 基础设施和资源限制了我们的尖端研究机会 州政府。为了实现这些目标，OCMP和I Cobre将以四个总体具体目标为指导 目标。具体目标1：建立一个专题中心，以加强研究、指导和 俄克拉荷马州微生物发病机制和免疫研究的基础设施支持 目标2：挑选和支持优秀的初级调查员，具体目标3：扩大和 加强基础设施，支持微生物领域的创新和合作研究 俄克拉荷马州的发病机制和免疫。具体目标4：培养协作文化和 团队科学，通过以下方式提供频繁的学术互动和外展机会 研讨会、专题讨论会、讲习班和试点项目。项目成功的关键因素 中心包括1)建立一个单一但高度灵活的研究中心，该中心可以 立即支持第一批初级调查员项目，并不断扩展以满足- 微生物发病机制和免疫研究需求的变化，2)最新进展 并使研究实验室空间现代化，初级调查人员可以与已建立的 调查人员并从日常互动中受益，3)开发未来青少年的渠道 通过有针对性的招聘和与部门网络的协作进行调查 多个园区的领导者，4)利用和利用现有的IDEA计划资源 俄克拉何马州，并利用正在进行的研讨会计划，赞助新的年度研讨会，以及 支持赠款撰写研讨会，以鼓励协作互动和思想交流 在这一多学科研究领域的研究人员中。总体而言，这五年 第一阶段Cobre计划将在俄克拉荷马州建立第一个卓越研究中心 专注于微生物的发病机制和免疫，成为加速 由这些领域的所有研究人员进行研究，并提供了一条高度支持的途径 我们最有前途的初级调查员的独立性。

Abstract The goal of this Phase-1 COBRE program is to develop and enhance the research infrastructure, mentoring, and collaborative environment to support five Junior Investigators in the multi-disciplinary fields of microbial pathogenesis and immunity. To achieve this goal, The Oklahoma Center for Microbial Pathogenesis and Immunity (OCMP&I) COBRE will be established and fostered as a center of excellence focused on advancing the careers of Junior Investigators studying life-threatening infectious microbes and the ways in which the immune system responds to infection. The OCMP&I COBRE will be centrally located at the University of Oklahoma Health Sciences Center, the flagship academic institution for biomedical research in Oklahoma. The OCMP&I COBRE will initially include 17 scientists engaged in microbial pathogenesis and immunity research at research-intensive institutions in Oklahoma and this network will be expanded during the Phase-1 period as the center takes form and grows. Among these 17 scientists are five outstanding and promising Junior Investigators who study fungal pathogenesis, inflammation, regulation of biofilms, and necrotizing enterocolitis. The OCMP&I and its consortium of successful senior researcher scientists will provide the intellectual input and expertise to mentor each Junior Investigator to research independence. In addition to outstanding mentoring, The OCMP&I COBRE will provide the funding and research core support needed for Junior Investigators to succeed and become long-term contributors to the microbial pathogenesis and immunity research community in Oklahoma. Intertwined with the Junior Investigator support, will be the OCMP&I COBRE's mission to address gaps in infrastructure and resources that have limited the opportunities for cutting-edge research in our state. To achieve these objectives, the OCMP&I COBRE will be guided by four overall specific aims. Specific Aim 1: Establish a thematic center to enhance research, mentoring, and infrastructure support for microbial pathogenesis and immunity research in Oklahoma, Specific Aim 2: Select and support outstanding Junior Investigators, Specific Aim 3: Expand and enhance infrastructure to support innovative and collaborative research in microbial pathogenesis and immunity in Oklahoma. Specific Aim 4: Foster a culture of collaboration and team-science by providing opportunities for frequent scholarly interactions and outreach through seminars, symposiums, workshops, and pilot projects. Key elements for the success of the center include 1) the establishment of a single, but highly facile research core, that can immediately support the first group of Junior Investigator projects and expand to meet ever- changing research needs of investigators in microbial pathogenesis and immunity, 2) up date and modernize research laboratory space where Junior Investigators can work with established investigators and benefit from daily interactions, 3) Develop a pipeline of future Junior Investigators through targeted hires and through collaboration with a network of departmental leaders on multiple campuses, 4) Utilize and capitalize on current IDeA program resources in Oklahoma, and 5) Utilize an ongoing seminar program, sponsor a new annual symposium, and support a grant-writing workshop to encourage collaborative interactions and exchange of ideas among investigators in this multi-disciplinary area of research. Collectively, this five-year Phase-1 COBRE program will establish the first center of research excellence in Oklahoma focused on microbial pathogenesis and immunity and become the central entity that accelerates research by all investigators in these fields and provides a highly-supportive path to independence for our most promising Junior Investigators.