PRIDE-Functional and Translational Genomics of Blood Disorders

摘要 缺乏多样性仍然是生物医学和行为科学研究项目中的一个重大挑战 和美国学术中心的教师构成。国家心肺血液研究所(NHLBI)资助 2006年的夏季学院增加多样性计划(SIPID)。随后，该方案增加了 从事健康相关研究的个体的多样性--人类功能基因组学和翻译基因组学 血液疾病(PROID-FTG)是在奥古斯塔大学建立的。通过Pride-FTG计划，我们 为76名代表不足的少数族裔初级教员调查员提供辅导培训。学员已学到 在连续两个暑期学院期间，实践板凳研究和施展技能。计划 评估支持实现我们的主要目标，即帮助学员提交NIH或同等学历 在项目完成后两年内提出赠款申请，NIH的赠款资金率为41.7%， 首席调查员。我们建议在Pride-FTG的下一次迭代中继续进行这种有指导的培训， 扩展到包括几个创新组件，并与肥胖健康差异组织合作- 骄傲计划，以汇集联邦资源。我们将测试这样一种假设，即建立一个有指导的培训计划 研究和赠款撰写技能将提高URM和残疾教师的能力，引导血液 障碍研究以获得校外资金并过渡到独立的研究事业。四个目标将 完成：目标1.在奥古斯塔大学开展创新暑期学院1(构成部分1)。 参加Pride-FTG计划的学员将参加包括以下内容的多学科课程 开展实际研究、培训和编写赠款活动，以制定筹资战略。目标2.支持 小型研究项目筹资倡议(构成部分4)。与PROCE指导委员会合作 和NHLBI计划工作人员，Pride-FTG计划将资助有重点的试点项目，以支持竞争性赠款 关于血液疾病研究的建议。目标3.促进指导和网络活动 (组件2)。导师委员会由一名被辅导者、一名骄傲研究导师和家庭组成 将建立机构导师。同行指导团队将在队列中启动，以促进研究 协作。该计划将支持年中访问导师的机构，并参加 全财团自豪感年会。目标4：开展创新暑期学院2(构成部分3)。 学员将返回奥古斯塔大学完成一对一的拨款审查，以实现以下主要目标 提交美国国立卫生研究院或同等资助金申请并参与其他研究的PROCE计划 经历。由Pride-FTG计划支持的导师培训将影响 代表不足和残疾的科学家取得成功的生物医学研究事业。

Abstract The lack of diversity remains a significant challenge in biomedical and behavioral science research programs and faculty composition in US academic centers. The National Heart, Lung, and Blood Institute (NHLBI) funded the Summer Institute Program to Increase Diversity (SIPID) in 2006. Subsequently, the Program to Increase Diversity Among Individuals Engaged in Health-Related Research-Functional and Translational Genomics of Blood Disorders (PRIDE-FTG) was established at Augusta University. Through the PRIDE-FTG program, we provided mentored training for 76 underrepresented minority junior faculty investigators. Mentees learned hands-on bench research and grantsmanship skills during two consecutive Summer Institutes. Program evaluation supports the achievement of our primary goal of aiding mentees to submit an NIH or equivalent grant application within two years of program completion, demonstrated by a 41.7% NIH grant-funding rate as principal investigator. We propose to continue this mentored training with the next iteration of PRIDE-FTG, expanded to include several innovative components and collaboration with the Obesity Health Disparities- PRIDE program to pool federal resources. We will test the hypothesis that a mentored training program to build research and grant-writing skills will increase the ability of URM and disabled faculty, conducting blood disorders research to obtain extramural funding and transition to independent research careers. Four aims will be accomplished: AIM 1. Conduct Innovative Summer Institute 1 at Augusta University (Component 1). Mentees matriculating into the PRIDE-FTG program will participate in a multidisciplinary curriculum including hands-on-bench research training and grant-writing activities to develop funding strategies. AIM 2. Support Small Research Project Funding Initiative (Component 4). In collaboration with the PRIDE Steering Committee and NHLBI program staff, the PRIDE-FTG program will fund focused pilot projects to support competitive grant proposals addressing blood disorders research. AIM 3. Facilitate Mentoring and Networking Activities (Component 2). Mentorship Committees comprised of a mentee, a PRIDE research mentor and home institution mentor will be established. Peer-mentorship teams will launch within cohorts to promote research collaboration. The program will support a mid-year visit to the mentor’s institution and attendance at the consortium-wide PRIDE annual meeting. AIM 4: Conduct Innovative Summer Institute 2 (Component 3). Mentees will return to Augusta University to complete a one-on-one grant review to meet the primary goal of the PRIDE program to submit an NIH or equivalent grant application and participate in additional research experiences. The mentored training supported by the PRIDE-FTG program will influence the number of underrepresented and disabled scientists achieving successful biomedical research careers.