MIRDP

申请人摘要： 本申请提出了将增强本领域技术人员的能力的研究项目。 我们机构进行药物滥用研究的能力。的 这项建议的目标是： 1)加强体制基础设施， 2)提高教师个人的表演能力 药物滥用研究，以及 3)让优秀学生参与研究，以鼓励他们 从事药物滥用研究 两个试点项目和八个单独的研究子项目， 提出了 这些试点项目将使两名初级教育工作者的职业发展成为可能， 从事药物滥用相关研究的教员。八种药物滥用- 相关的子项目将使教师和优秀学生， 实现以下具体目标。对吸烟的评价 将采用终止方法。三维结构 并测定可卡因类似物的电子特征。一个 中枢苯二氮卓受体的内源性配体将被 鉴定将开发缓释药物递送系统用于 治疗毒瘾例如，可生物降解的微胶囊 将开发并评价含丁丙诺啡的药物 特色此外，本发明还提供了一种口服微胶囊制剂， 将开发并评价金刚烷胺的释放特性 in vitro体外and in vivo体内experiments实验.酗酒的流行程度 路易斯安那州的黑人青少年人口相对于其他种族 青少年将与社会经济和文化 开始饮酒、家庭态度和信念、同伴 压力，学习成绩，以及饮酒的理性新无环 抗艾滋病的核苷酸类似物将被合成为潜在的抗艾滋病病毒 治疗HIV-1和3 ′-叠氮胸苷（AZT）抗性HIV-1的药物 艾滋病患者中的菌株。新型抗卡氏肺孢子虫药物 将合成较少的肝毒性，从而能够改进药物治疗 酒精性艾滋病患者的肝脏损伤。

APPLICANT'S ABSTRACT: The present application proposes research projects that will enhance the ability of our institution to conduct drug abuse research. The objectives of this proposal are: 1) to strengthen the institutional infrastructure, 2) To enhance the capability of individual faculty members to perform drug abuse research, and 3) To involve outstanding students in research in order to encourage them to pursue careers in drug abuse research. Two pilot projects and eight individual research subprojects are proposed. The pilot projects will enable the career development of two junior faculty members in drug abuse-related research. The eight drug abuse- related subprojects will enable faculty and outstanding students to accomplish the following specific aims. An evaluation of smoking cessation methods will be performed. The three-dimensional structure and electronic character of cocaine analogs will be determined. An endogenous ligand of the central benzodiazepine receptor will be identified. Slow release drug delivery systems will be developed for treating drug addictions. For example, biodegradable microcapsules containing buprenorphine will be developed and evaluated for release characteristics. In addition, an oral microcapsule formulation of amantidine will be developed and evaluated for release characteristics in in vitro and in vivo experiments. The prevalence of alcoholism in the black adolescent population of Louisiana relative to other ethnic adolescents will be contrasted with socioeconomic and cultural differences in onset of alcohol use, family attitudes and beliefs, peer pressure, school performance, and rational for drinking. New acyclic nucleotide analogs of anti-AIDS will be synthesized as potential anti-HIV agents for treatment of HIV-1 and 3'-azidothymidine (AZT) resistant HIV-1 strains in AIDS patients. Novel anti-Pneumocystis carinii drugs with less hepatotoxicity will be synthesized to enable improved drug therapy of alcoholic AIDS patients with liver damage.