LONGITUDINAL STUDY OF PREOSTEOPOROSIS POPULATION

描述：(改编自《调查者摘要》)本项目 包括对高危人群的纵向、前瞻性研究 治疗骨质疏松症。研究对象为191名老年正常女性 在1967年研究开始时是35-45。已经做出了一些观察 每五年一次，包括人口统计，人体测量，钙 动力学、钙代谢、荷尔蒙和生理测量， 以及骨骼的射线照相和光子密度计测量 质量。 该项目的目的是：(1)获得全面的纵向 各种钙和骨代谢指标及相关指标的数据 一组未接受治疗的妇女的生理功能 围绝经期至出现骨质疏松症状的时间； 提供了一份详尽的生理档案 随后出现症状性骨质疏松症，而那些没有出现症状的人， 从而允许对两者之间的差异进行前瞻性表征 以及影响该等差异的因素；。(三)准许 更好地识别易患骨质疏松症的亚群，从而 为预防治疗提供了合理的依据，也为预防治疗提供了合理的依据 确定应成为其目标的主体；(4)确定 主要生理变量之间的横截面相互关系 在骨质疏松症发展的关键时期；以及最后(5) 提供一个全面的数据库来测试关于以下方面的假设 申请者和其他人开发的变量之间的关联 不在这项提议的背景下。 下一批款期的计划是：(1)继续监察 这一队列直到出现足够数量的骨质疏松相关骨折 发展，以及(2)继续获得主要结果指标(例如骨骼 肿块、骨折)每三年。在新项目开始时 研究人群的年龄将在63-72岁之间。四十七岁 到目前为止，队列中可能已经发生了与脆性相关的骨折。

DESCRIPTION: (Adapted From Investigator's Abstract) This project consists of a longitudinal, prospective study of the population-at-risk for osteoporosis. Research subjects are 191 normal women who were aged 35-45 at the start of the study in 1967. Observations have been made once every five years consisting of demographic, anthropometric, calcium kinetic, calcium metabolic, hormonal, and physiological measurements, as well as radiogrammetric and photon-densitometer measurement of bone mass. The purposes of the project are: (1) to obtain comprehensive longitudinal data on various measures of calcium and bone metabolism and related physiological functions in a group of untreated women from the perimenopausal period to the time of osteoporotic symptoms; (2) to provide an exhaustive physiological profile both on women who subsequently develop symptomatic osteoporosis and on those who do not, thereby allowing prospective characterization of the differences between them and of the factors influencing those differences; (3) to permit better identification of the osteoporosis-prone subset and thereby to provide both a rational basis for prophylactic treatment and the identification of subjects who should be its target; (4) to characterize cross-sectional inter-relationships between major physiologic variables during this key era of osteoporosis development; and finally (5) to provide a comprehensive database for testing hypotheses about associations among variables developed by the applicants and others outside the context of this proposal. The plan for this next grant period is to: (1) maintain surveillance of this cohort until a sufficient number of osteoporosis-related fractures develop, and (2) to continue obtaining major outcome measures (e.g. bone mass, fractures) every three years. At the onset of the new project period the study population will be in the age-range 63-72. Forty-seven probably fragility-related fractures have occurred in the cohort to date.