TISSUE OXYGEN MONITOR

描述：（改编自申请人的摘要）这是一个 重新提交先前的申请。在这个项目中，目标是 一种微型电化学氧传感器的研制 电极设计该传感器将被制造在一个孔内， 小（28号，.23 mm ID）皮下注射针。该设备将 用醋酸纤维素膜保护， 技术.该设备将能够持续监测 用于插入皮瓣或游离肌肉移植 在重建手术后。该传感器基于先前 开发的技术尚未公开。 新 解决以往规模和脆弱性问题的施工技术 将得到发展。实验室研究将使用 氧合生理盐水用于常规评价，小牛血清用于检测 传感器对组织间液污染的抵抗力， 包括最终的操作环境 拟议商业应用：基于潜在指示 组织缺氧，虽然在局部水平，该设备有可能 成功打入失血检测临床市场 流入重建手术部位

DESCRIPTION: (Adapted from the applicant's abstract) This is a resubmission of an earlier application. In this program, the goal is the development of a miniature electrochemical oxygen sensor of a three electrode design. The sensor will be fabricated within the bore of a small (28 gauge, .23 mm ID) hypodermic needle. The device will be protected with a cellulose acetate membrane fabricated by proprietary techniques. The device will be capable of continuously monitoring oxygen and is intended for insertion in flap or free muscle transplants after reconstructive surgery. The sensor is based on previously developed technology that has not been publically disclosed. New construction techniques that address previous size and fragility issues will be developed. Laboratory studies will be performed using oxygenation saline for routine evaluation and calf serum to test for resistance of the sensor to contamination by the interstitial fluid that comprises the ultimate operating environment PROPOSED COMMERCIAL APPLICATION: Based on the potential to indicate tissue hypoxia, albeit at a local level, this device has the potential to successfully penetrate the clinical market for detecting loss of blood flow into reconstructive surgical sites.