CANCER EPIDEMIOLOGY OF MIGRANT JAPANESE IN HAWAII

这是一项流行病学前瞻性研究，旨在确定生化， 饮食和其他与美国人癌症发生有关的因素 住在夏威夷的日本男人。该提案的重点是两个具体的 癌症部位：前列腺癌和结肠癌。五个具体目标将是 收件人：L)确定膳食脂肪或维生素A摄入量是否增加 前列腺癌风险；2)研究血清水平与前列腺癌的关系 维生素A和类胡萝卜素与前列腺癌风险，使用诊断前 血清；3)看看血清肾上腺雄激素水平升高和其他 雄激素(雄酮葡萄糖醛酸苷和5-α-雄烷-3-α，17- β-二醇葡萄糖醛酸脂)会增加前列腺癌的风险；4)看看高 摄入膳食脂肪会增加患结肠癌的风险；5)以确定 高水平的血清维生素D可以预防结肠癌。

This is an epidemiologic prospective study to identify biochemical, dietary and other factors related to cancer occurring among American Japanese men living in Hawaii. The proposal is focused on two specific cancer sites: the prostate and colon. Five specific aims will be addressed: l) to determine if dietary fat or vitamin A intake increases prostate cancer risk; 2) to study the association of serum levels of vitamin A and carotenoids with prostate cancer risk, using pre-diagnostic serum; 3) to see if elevated serum levels of adrenal androgens and other androgens (androsterone glucuronide and 5-alpha-androstane-3-alpha, 17- beta-diol glucuronide) increase prostate cancer risk; 4) to see if a high intake of dietary fat increases colon cancer risk; 5) to determine if high serum levels of vitamin D protect against colon cancer.