A Multi-Optrode Array for Closed-Loop Bionics

我们将设计、实现和表征一种破坏性多通道光电阵列（MOA），以记录和刺激可兴奋的活组织。MOA将是单个光学电极（optrodes）的组合，其中包括一种新型液晶（用于被动感知细胞外生物电位）或微光伏电池（用于可兴奋组织的电刺激）。通过利用光与电极进行通信，这种新方法减轻了与现有设备相关的许多布线，封装和封装问题。心脏组织和视网膜神经元的计算模型和体外测试将证明MOA在感知和控制电活动方面的效用。

We will design, implement and characterise a disruptive multi-channel optrode array (MOA) to record and stimulate excitable living tissue. The MOA will be a combination of individual optical electrodes (optrodes) that either comprise a new class of liquid crystals, used to passively sense extracellular biopotentials, or microphotovoltaic cells that will be used for electrical stimulation of excitable tissue. By employing light for communication with optrodes, this new approach alleviates many of the wiring, packaging and encapsulation issues associated with existing devices. Computational modelling and in vitro testing in cardiac tissue and retinal neurons will demonstrate the utility of the MOA to sense and control electrical activity.