NICOTINE REPLACEMENT--EFFECTS OF COST & MINIMAL SUPPORT

尼古丁替代品已成为治疗吸烟依赖的一种 流行但有争议的治疗形式有很多种方法 尼古丁可以服用，因此可以有更多的选择 个体化治疗。然而，其中一个争议是关于 尼古丁替代是指它本身是有效的，还是只在 行为治疗计划的背景。此外，还有一种担忧， 一些使用尼古丁替代品的人会变得依赖 这种形式的尼古丁。 不幸的是，很少有研究评估这种药物的疗效和长期使用。 尼古丁替代治疗在非常微小的背景下 行为治疗计划，甚至更少的人评估了这种依赖 尼古丁替代产品的潜力。建议进行的研究包括 旨在评估尼古丁贴片和口香糖的安全性和有效性 真正的自助计划。不会有戒烟的建议 他向受试者提供。 前两项建议的研究是随机、双盲、安慰剂- 受控临床试验旨在单独评估(1) 尼古丁口香糖和贴片使用时间更长的可能性 比推荐值高(与吸烟状态无关)和(2) 尼古丁口香糖和贴片在自助戒烟中的作用 协议。前两项研究的治疗条件如下： 研究1：15毫克尼古丁或安慰剂透皮贴片，研究2：4毫克， 2毫克，或安慰剂口香糖。 第二项研究是随机临床试验，旨在 分别评估(1)尼古丁贴片和口香糖成本对 药物使用，(2)这些产品将被用于 比建议的时间更长，以及(3)禁酒率为4毫克 尼古丁口香糖和15毫克尼古丁贴片(3Ocm2)作为药物的作用 后两项研究中的成本处理条件如下：研究 #3：15毫克尼古丁贴片，全价(每盒50美元，共14盒)，半价 (25美元/盒)，或者免费，研究4：全价4毫克尼古丁口香糖 (66美元/盒96件)，半价(33美元/盒)，或免费。 建议的研究结果可以使我们更好地理解 尼古丁替代产品在最小行为障碍时的疗效 在费用不同的情况下提供治疗。结果也可能是 帮助制定有关向Over-Over的潜在转换的决策 柜台用药情况。

Nicotine replacement for the treatment of smoking dependence has become a popular yet controversial form of treatment There are many ways in which nicotine can be administered, thus allowing for more options for individualized treatment. However, one of the controversies regarding nicotine replacement is whether it is efficacious by itself or only in the context of a behavioral treatment program. In addition, there is concern that some of those who use nicotine replacement will become dependent on that form of nicotine. Unfortunately, few studies have assessed the efficacy and long term use of nicotine replacement treatments in the context of a very minimal behavioral treatment program, and even fewer have evaluated the dependence potential of nicotine replacement products. The proposed studies were designed to assess the safety and efficacy of nicotine patch and gum in a truly self-help program. No recommendations about smoking cessation will he provided to subjects. The first two proposed studies are randomized, double-blind, placebo- controlled clinical trials designed to separately assess (1) the likelihood that nicotine gum and patch will be used for longer periods than recommended (regardless of smoking status) and (2) the efficacy of nicotine gum and patch as aids to smoking cessation in a self-help protocol. Treatment conditions in the first two studies are as follows: Study #1: 15 mg nicotine or placebo transdermal patch, and Study #2: 4 mg, 2 mg, or placebo gum. The second two studies are randomized clinical trials designed to separately evaluate (1) the effect of nicotine patch and gum cost on medication use, (2) the likelihood that these products will be used for longer periods than recommended, and (3) the abstinence rates of 4 mg nicotine gum and 15 mg nicotine patch (3Ocm2) as a function of medication cost Treatment conditions in the second two studies are as follows: Study # 3:15 mg nicotine patch at full price ($5O/box of 14), half price ($25/box), or at no cost, and Study #4: 4 mg nicotine gum at full price ($66/box of 96 pieces), half price ($33/box), or at no cost. The results of the proposed studies can lead to a better understanding of the efficacy of nicotine replacement products when minimal behavioral treatment is provided and when costs are varied. The results could also contribute to decision-making regarding the potential switch to over-the- counter medication status.