Novel mechanisms for regulating the retinal vasculature

严格控制视网膜血管系统对维持正常视力至关重要。与身体中的大多数血管不同，视网膜和大脑中的血管没有直接的神经控制。相反，它们依靠支持细胞来传达神经元的需求。该项目旨在研究驻留免疫细胞（称为小胶质细胞）在神经活动下调节视网膜毛细血管的机制。将产生检验新机制的新知识。这一信息对于增强我们对视网膜和大脑中血管如何被控制的理解至关重要，并将指导检查血管功能的新方法的发展。

Tight control of the retinal vasculature is crucial for maintaining normal vision. Unlike most blood vessels in the body, those in the retina and brain receive no direct neural control. Rather they rely on support cells to communicate the needs of neurons. This project aims to examine the mechanisms by which resident immune cells, called microglia, regulate retinal capillaries in response to neural activity. New knowledge examining a novel mechanism will be generated. This information is crucial for enhancing our understanding of how blood vessels are controlled in the retina and brain and will guide the development of novel ways of examining blood vessel function.