GENETICS OF AFFECTIVE DISORDERS

这项拟议研究的主要目标是检测基因效应。 患有躁郁症和相关的情感障碍。这个目标一定会实现的 通过1.收集分离这些品种的扩展的高密度家系 疾病；2.临床表型的特征使用综合 临床分级和操作诊断标准；3.进行 利用DNA标记进行连锁研究；4.对连锁进行重新评估 具有X连锁证据的先前已鉴定的家系的结果 通过扩展和更新临床和基因传播 信息。在等待连锁分析的结果之前，远程 目标将包括：疾病的识别和特征 基因(S)；连锁疾病的临床和临床特征 生物学措施；基因-环境相互作用的阐明； 扩大血统名册，以复制联系成果和 评估病因学的异质性；以及旨在扩大 并更新已经确定的谱系。三个种群将是 研究：一个普通的北美样本；一个犹太裔美国人(哈西德) ‘隔离’；和一个以色列样本。这应该允许评估 种群间的遗传和文化差异。是否可以使用 一系列独特的家系，加上最近在诊断方面的进展 程序、分子遗传技术和连锁分析， 有望解开某些形式背后的遗传机制 严重的情感疾病。反过来，这可能会对 病因学，病因学，病理生理学，可能还有， 预防、治疗和治疗这些疾病。 候选人的持续职业发展将持续和 由1.在进行 拟议的研究；2.与 该领域的其他专家；3.该领域的课程、研讨会和讲习班 相关学科；以及4.利用独特的部门 致力于精神病学遗传学的资源和环境。

The broad objective of the proposed research is to detect gene effects in bipolar and related affective disorders. This goal will be attained by 1. collecting extended high-density pedigrees segregating these disorders; 2. characterizing the clinical phenotype using comprehensive clinical ratings and operational diagnostic criteria; 3. conducting linkage studies with DNA markers; and 4. re-evaluating the linkage results in previously identified pedigrees with evidence of X-linked transmission by extending and updating the clinical and genetic information. Pending the results of the linkage analyses, long-range goals will include: identification and characterization of the disease gene(s); characterization of linked disease forms on clinical and biological measures; elucidation of gene-environment interaction; expansion of the pedigree roster to replicate linkage results and to assess etiologic heterogeneity; and a follow-up study aimed at extending and updating the pedigrees already identified. Three populations will be studied: a general North-American sample; a Jewish-American (Hasidic) 'isolate'; and an Israeli sample. This should allow assessment of genetic and cultural differences among populations. The availability of a unique series of pedigrees, coupled with recent advances in diagnostic procedures, molecular genetic techniques, and linkage analysis, holds promise for unraveling the genetic mechanisms that underlie some forms of major affective illness. This, in turn, may have important implications for the etiology, nosology, pathophysiology and, possibly, prevention and treatment and treatment of these disorders. The candidate's continued professional growth will be sustained and fostered by 1. the experience to be gained during the conduct of the proposed research; 2. extensive collaborations and consultations with other experts in the field; 3. courses, seminars and workshops in the relevant disciplines; and 4. utilization of unique departmental resources and environment dedicated to psychiatric genetics.