DIAGNOSTIC IMAGING OF SKIN

这项研究将开发一种光学仪器来辅助无创 评估受损伤、外科手术和/或疾病影响的皮肤。 该仪器将利用血红蛋白对光的吸收特性 用于描绘因缺血、缺氧或缺氧而受损的皮肤区域的物种 坏死。这项研究是基于这样一个假设： 皮肤中色素的反射光谱提供的信息可以 用于定位和评估皮肤受损区域。在第一阶段a期间 将建造皮肤成像系统，以获得反射图像 皮肤发出的可见光和近红外线波长。波长将是 被选来监测血红蛋白吸收和组织光的变化 散开。L阶段研究将论证工作的可行性 以大鼠带蒂皮瓣为模型的假说及设计 二期临床用仪器的建造参数 审判。在阶段LI成像系统将接受临床测试，以 确定系统辅助评估血管的能力 疾病、烧伤、伤口愈合和重建手术。这台仪器 将为临床医生提供一种真正意义上的 非侵入性，不需要注射或皮肤接触。它将提供 快速、易于解释的图像显示，在技术上易于使用。

This research will develop an optical instrument to aid in the noninvasive evaluation of skin affected by injury, surgical procedures and/or disease. The instrument will use characteristics of light absorption by hemoglobin species to delineate skin regions compromised by ischemia, hypoxia or necrosis. This research is based on the working hypothesis that reflectance spectra of pigments in skin provide information that can be used to locate and evaluate compromised regions of skin. During Phase I a skin imaging system will be constructed to obtain reflectance images at visible and near-infrared wavelengths from skin. Wavelengths will be chosen to monitor changes in hemoglobin absorption and tissue light scatter. Phase l studies will demonstrate feasibility of the working hypothesis using the rat pedicle skin flap as a model and provide design parameters for instruments to be constructed during Phase ll for clinical trials. During Phase lithe imaging system will undergo clinical testing to determine the system's ability to assist in the evaluation of vascular disorders, burns, wound healing and reconstructive surgery. The instrument will provide clinicians with a noncontact diagnostic method that is truly noninvasive and requires no injections or skin contact. It will provide rapid, easily interpreted image displays and be technically easy to use.