FUNCTIONAL ORGANIZATION OF THE SOMATOSENSORY SYSTEM

计划在猴子身上进行几种类别的实验 更好地了解组织、开发、 和损伤相关的感觉和运动系统的可塑性 人类。(1)正常的组织和连接模式 在大脑皮层、脑干和脊髓水平进行研究 使用微电极标测方法、单单元记录、 以及一系列的解剖示踪剂。此信息是以下方面的基本信息 对高等灵长类感觉系统如何复杂的理解 处理信息并产生运动模式。结果还包括 作为伤害调查的对照和对照 成体和发育系统的诱导可塑性。(2)有限公司 大脑皮层感觉的正常发育研究 制图表达和连接将使用相同的方法，并且 在理解正常发展和如何发展方面都很重要 对发育中系统的伤害可能会改变发育。(3)大调 研究计划的一部分将针对理解 成人和发育中的体感系统如何重组为 周围神经损伤伴和不伴再生的结果。 我们将研究手部的皮质表现，以 微电极标测对正常组织结构的改变 方法，以及再生和邻近完好无损的条件 神经将通过解剖追踪进行独立评估 方法：研究方法。结果将对以下方面产生重大影响 对老年人神经和脑损伤后果的认识 成人和发育中的人类，并应提供信息 与修复和治疗策略相关。此外， 研究结果将对构建和修正 神经系统如何发展和自我组织。

Several categories of experiments on monkeys are planned with the broad goal of better understanding the organization, development, and injury related plasticity of sensory and motor systems in humans. (1) Normal organization and connection patterns will be investigated at cortical, brainstem, and spinal cord levels with the use of microelectrode mapping methods, single unit recordings, and a range of anatomical tracers. This information is basic for understandings of how complex sensory systems of higher primates process information and produce motor patterns. The results also serve as a comparison and control for investigation of injury induced plasticity in adult and developing systems. (2) Limited studies on the normal development of cortical sensory representations and connections will use the same methods, and will be important in both understanding normal development and how injury to developing systems can alter development. (3) A major part of the research program will be directed toward understanding how adult and developing somatosensory systems reorganize as a result of peripheral nerve injury with and without regeneration. Cortical representations of the hand will be studied for alterations from normal organization with microelectrode mapping methods, and the condition of regenerated and adjacent intact nerves will be evaluated independently with anatomical tracing methods. The results will have major implications for understanding of the consequences of nerve and brain injury in adult and developing humans, and should provide information relevant to repair and treatment strategies. In addition, the results will be important in constructing and revising theories of how the nervous system develops and self-organizes.