Functional Organization of the Somatosensory System

体感系统的功能组织

• 批准号: 7822703
• 负责人: JON H KAAS
• 金额: $ 42.5万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-07-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7822703
• 关键词: Antibodies; Area; Astrocytes; Axon; Behavioral; Biological Preservation; Brain Stem; Brain-Derived Neurotrophic Factor; Cell Nucleus; Cervical; Chondroitin ABC Lyase; Chronic; Complement; Contralateral; Cutaneous; Deafferentation procedure; Digestion; Digit structure; Effectiveness; Electrodes; Enhancing Lesion; Enzymes; Evaluation; Excision; Extracellular Matrix; Glutamate Transporter; Growth; Growth Associated Protein 43; Growth Inhibitors; Hand; Hand functions; Human; Label; Left; Lesion; Maps; Mediating; Methods; Microelectrodes; Microtubule-Associated Protein 2; Neurons; Nogo protein; Population; Presynaptic Terminals; Procedures; Process; Property; Proteins; Recovery; Research; Sensory; Somatosensory Cortex; Spinal Cord; Spinal Cord Part; Spinal cord injury; Stimulus; Structure of nucleus cuneatus; System; Tactile; Thalamic structure; Therapeutic; Time; axon growth; axonal sprouting; behavior measurement; density; design; dorsal column; human RTN4 protein; immunocytochemistry; improved; nerve supply; neurite growth; neurofilament; new growth; public health relevance; response; somatosensory

Description (provided by applicant): After damage to afferents from the hand as they course in the dorsal columns of the spinal cord, deprived portions of the brainstem cuneate nucleus, somatosensory thalamus, and somatosensory cortex become unresponsive to tactile stimuli and hand use is impaired. However, within 1 - 2 months, cortex can be reactivated by a few surviving dorsal column afferents, and hand use improves. We will evaluate the relationships between (1) the recovery of hand use, (2) the time course of the reactivation of cortex, (3) the recovery of response properties of cortical neurons, (4) the sprouting and growth of surviving dorsal column afferents in the cuneate nucleus of the lower brainstem to contact more neurons, and (5) the cellular and histochemical consequences in the cuneate nucleus of partial deafferentation. In addition, we will evaluate the effectiveness of two treatments, (6) chondroitinase ABC and (7) anti-Nogo-A, on sprouting new growth of surviving dorsal column afferents in the cuneate nucleus. The research is designed to provide an understanding of the major mechanisms of recovery of somatosensory system function after a sensory loss in humans, and to help develop favorable therapeutic approaches for humans with sensory loss after spinal cord injury. PUBLIC HEALTH RELEVANCE: The proposed research seeks to evaluate the hypothesis that a few preserved sensory afferents in the dorsal columns of the spinal cord injury can mediate the recovery of hand use by sprouting to activate a large population of neurons in the brainstem and thereby, the cortex. The proposed research will also evaluate two treatments that are likely to promote the growth of the preserved sensory afferents.

描述(申请人提供)：当手部的传入神经在脊髓的背侧柱中运动时受到损害后，脑干楔状核、体感丘脑和体感皮质的剥夺部分对触觉刺激变得没有反应，手的使用受到损害。然而，在1-2个月内，皮质可以被少数存活的背柱传入重新激活，手使用能力得到改善。我们将评估(1)恢复双手使用，(2)皮质重新激活的时间进程，(3)皮质神经元反应特性的恢复，(4)存活的背柱传入在脑干下部的楔状核中萌发和生长以接触更多的神经元，以及(5)部分去传入在楔状核内的细胞和组织化学后果。此外，我们还将评估两种治疗方法，(6)软骨素酶ABC和(7)抗Nogo-A，对存活的背柱传入神经在楔状核内萌发新芽的效果。这项研究旨在了解人类感觉丧失后躯体感觉系统功能恢复的主要机制，并帮助为脊髓损伤后感觉丧失的人类开发有利的治疗方法。公共卫生相关性：这项拟议的研究试图评估一种假设，即脊髓损伤背侧柱中保存下来的几个感觉传入可以通过萌芽激活脑干中的大量神经元从而激活皮质来调节手的恢复使用。这项拟议的研究还将评估两种可能促进保存下来的感觉传入生长的治疗方法。