Area 3b hand cortex in primate: the targets and sources of extra-hand suppressive surrounds

灵长类动物的 3b 区手皮层：额外手抑制环境的目标和来源

• 批准号: 10567355
• 负责人: JON H KAAS
• 金额: $ 38.67万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10567355
• 关键词: Affect; Area; Behavior; Cell Nucleus; Characteristics; Complex; Contralateral; Data; Disinhibition; Electrodes; Evolution; Feedback; Hand; Hand functions; Impairment; Ipsilateral; Lesion; Location; Manuals; Maps; Mediating; Methods; Monkeys; Neurons; Pathway interactions; Primates; Process; Qi; Recovery; Research; Rest; Sensory; Site; Skin; Somatosensory Cortex; Source; Spinal Cord; Spinal Cord Lesions; Spinal cord injury; Stimulus; Structure of nucleus cuneatus; System; Tactile; Thalamic structure; Therapeutic Intervention; Touch sensation; dorsal column; excitatory neuron; hand dysfunction; inhibitory neuron; long term recovery; neural; receptive field; sensory input; somatosensory; tactile stimulation

Summary Our previous studies have revealed a complex organization of receptive fields (RFs) of neurons in primary somatosensory cortex of monkeys (area 3b). The neurons have small excitatory centers that create the somatotopic map of the hand, a suppressive surround that includes all of the rest of the glabrous hand, and a weaker suppressive surround that includes all of the skin on the other hand (the “extra hand” surround). We propose to determine if neurons in different layers have similar or different surrounds, what surround features are relayed from the thalamus to area 3b neurons, and the connections that mediate different parts of the surround by inactivating cortical areas that directly or indirectly provide feedback to area 3b hand neurons. In addition, we will determine how a major loss of sensory inputs from the hand, due to selective spinal cord lesions, alters the center-surround relationships of neurons in the deprived and non-deprived 3b hand cortex, even after extensive post lesion recovery of 3b reactivation and hand use. The expected results will greatly expand our understanding of how tactile information from the hands is processed in the somatosensory system, and how processing is impaired and recovered following sensory loss. These results will have a clear impact on therapeutic intervention following spinal cord injury.

概括 我们之前的研究揭示了初级神经元感受野（RF）的复杂组织 猴子的体感皮层（区域 3b）。神经元有小的兴奋中心，可以产生 手的体位图，包括无毛手的所有其余部分的抑制性周围，以及 较弱的抑制环绕，包括另一只手的所有皮肤（“额外的手”环绕）。我们 提出确定不同层中的神经元是否具有相似或不同的周围环境，以及什么周围特征 从丘脑传递到 3b 区神经元，并且介导丘脑不同部分的连接 周围是失活的皮层区域，这些区域直接或间接地向 3b 区手部神经元提供反馈。在 此外，我们将确定由于选择性脊髓导致手部感觉输入的重大损失是如何发生的 损伤，改变剥夺和非剥夺 3b 手皮层神经元的中心-周围关系， 即使在 3b 重新激活和手部使用的广泛损伤后恢复之后。预期效果将大大 扩展我们对体感神经系统如何处理手部触觉信息的理解 系统，以及感觉丧失后处理如何受损和恢复。这些结果将有一个明确的 对脊髓损伤后治疗干预的影响。