ORGANIZATION OF AUDITORY CORTEX

描述：(改编自申请人的摘要)长期 本项目的目标是描述(1)听觉的细分 灵长类动物的大脑皮层，(2)它们与额叶和 边缘系统，以及(3)视觉和听觉通路的汇聚。 所有这三个目标都将通过结合微电极进行研究 新大陆平行实验中的记录和解剖技术 猫头鹰猴子(因为它们的皮层相对不裂开且容易接近)， 和东半球猕猴(因为它们与 人类)。这个项目的一个主要焦点是研究大脑皮层和 丘脑AI、R(或RL)和周围听带的连接 大脑皮层。这将通过注入2-3种不同的 使用最佳频率图跟踪AI和R，以及单个神经元 对声音方向和声级的选择性，以识别注射部位。 结果将提供有关地形组织的信息 AI和R的丘脑和皮质与强直性的联系 等频等高线内的组织和表示。 皮质带的细分，由它们与大脑皮质的连接模式定义 AI和R，则会被注入与其连接更远的地方 检查听觉皮质、额叶和边缘结构的区域。这个 从皮质区和皮质区多次注射收集的数据 邻近的听觉领域，将导致这一主要目标的第三个 项目，该项目将定义视觉和听觉的融合区域 信息。在这些实验中，在体内注射不同的示踪剂 由电生理学识别为视觉或听觉的皮质区域 记录和/或与视觉和听觉的生理地图的连接 皮质将提供关于两者的起源和相互作用的信息 灵长类动物大脑皮质和丘脑的感觉系统。

DESCRIPTION: (ADAPTED FROM THE APPLICANT'S ABSTRACT) The long-term objectives of this project are to describe (1) the subdivisions of auditory cortex in primates, (2) their connection patterns with the frontal lobe and limbic system, and (3) the convergence of visual and auditory pathways. All three objectives will be investigated by combining microelectrode recordings and anatomical techniques in parallel experiments on New World owl monkeys (for their relatively unfissured and easily accessible cortex), and Old World macaque monkeys (for their close phylogenetic relation to humans). A major focus of this project is to study the cortical and thalamic connectivity of AI, R (or RL), and the surrounding auditory belt cortex. This will be accomplished by placing injections of 2-3 different tracers into AI and R using best frequency maps, and single neuron selectivities to sound direction and level to identify injection sites. The results will provide information on the topographic organization of thalamic and cortical connections of AI and R with respect to tonotopic organizations and representations within an isofrequency contour. Subdivisions of the belt cortex defined by their connection patterns with AI and R, will then be injected and their connections with more distant areas of auditory cortex, frontal lobe and limbic structures examined. The data gathered from these multiple injections in the belt cortex and adjacent auditory fields, will lead to the third major goals of this project, which is to define areas of convergence of visual and auditory information. In these experiments, injections of different tracers in regions of cortex identified as visual or auditory by electrophysiological recording and/or connections with physiological maps of visual and auditory cortex will provide information on the origin and interaction of the two sensory systems in the cortex and thalamus of primates.