ORGANIZATION OF AUDITORY CORTEX

听觉皮层的组织

• 批准号: 3217668
• 负责人: JON H KAAS
• 金额: $ 11.28万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-02 至 1993-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3217668
• 关键词: Aotus; Macaca fascicularis; Macaca mulatta; auditory cortex; auditory pathways; auditory stimulus; brain electrical activity; brain mapping; evolution; fluorescent dye /probe; frontal lobe /cortex; histology; limbic system; microelectrodes; microinjections; peroxidases; single cell analysis; thalamus; visual pathways

DESCRIPTION: (ADAPTED FROM THE APPLICANT'S ABSTRACT) The long-term objectives of this project are to describe (1) the subdivisions of auditory cortex in primates, (2) their connection patterns with the frontal lobe and limbic system, and (3) the convergence of visual and auditory pathways. All three objectives will be investigated by combining microelectrode recordings and anatomical techniques in parallel experiments on New World owl monkeys (for their relatively unfissured and easily accessible cortex), and Old World macaque monkeys (for their close phylogenetic relation to humans). A major focus of this project is to study the cortical and thalamic connectivity of AI, R (or RL), and the surrounding auditory belt cortex. This will be accomplished by placing injections of 2-3 different tracers into AI and R using best frequency maps, and single neuron selectivities to sound direction and level to identify injection sites. The results will provide information on the topographic organization of thalamic and cortical connections of AI and R with respect to tonotopic organizations and representations within an isofrequency contour. Subdivisions of the belt cortex defined by their connection patterns with AI and R, will then be injected and their connections with more distant areas of auditory cortex, frontal lobe and limbic structures examined. The data gathered from these multiple injections in the belt cortex and adjacent auditory fields, will lead to the third major goals of this project, which is to define areas of convergence of visual and auditory information. In these experiments, injections of different tracers in regions of cortex identified as visual or auditory by electrophysiological recording and/or connections with physiological maps of visual and auditory cortex will provide information on the origin and interaction of the two sensory systems in the cortex and thalamus of primates.

说明：（根据申请人摘要改编） 本项目的目标是描述（1）听觉的细分 灵长类动物的大脑皮层，（2）它们与额叶的连接模式， 边缘系统;（3）视觉通路和听觉通路的会聚。 所有这三个目标将被调查，结合微电极 新大陆平行实验中的记录和解剖技术 猫头鹰猴（因为它们的皮质相对无裂隙且容易接近）， 和旧大陆猕猴（因为它们与 人类）。 该项目的一个主要重点是研究大脑皮层和 丘脑连接的AI，R（或RL），和周围的听觉带 皮层 这将通过注射2-3种不同的 使用最佳频率图和单个神经元跟踪AI和R 选择性的声音方向和水平，以确定注射部位。 其结果将提供有关地形组织的信息， 丘脑和皮质的联系，AI和R的音调 组织和表示在一个ISOTORCH轮廓。 带状皮层的细分由它们与 AI和R，然后将被注入，它们与更远的 检查听觉皮层、额叶和边缘结构的区域。 的 从带状皮层中的这些多次注射中收集的数据， 相邻的听觉领域，将导致第三个主要目标， 该项目旨在确定视觉和听觉融合的领域， 信息. 在这些实验中，将不同的示踪剂注射到 通过电生理学鉴定为视觉或听觉的皮层区域 记录和/或连接视觉和听觉的生理图 大脑皮层将提供有关两者起源和相互作用的信息。 灵长类大脑皮层和丘脑的感觉系统。