Closing the data gap: High throughput screening of nanoparticle toxicity

纳米技术部门正在经历一个指数增长期，每年有100多种含有人造纳米颗粒的产品进入市场。确保该部门的增长需要与保护人类和环境安全的当务之急相平衡。该项目旨在开发新的方法和概念途径，以缩小纳米技术创新和风险评估之间的差距。这是为了通过开发和验证制造的纳米颗粒的高通量体外毒性筛选平台来实现的。该方法基于先进的芯片实验室微流控技术。该平台的预测能力将通过体外和体内模型进行细化和优化。

The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk assessment. This is intended to be achieved by developing and validating high-throughput in vitro toxicity screening platforms for manufactured nanoparticles. The approach is based on advanced lab-on-a-chip microfluidic technologies. The predictive power of the platform will be refined and optimised via ex-vivo and in-vivo models.