CHRONIC STUDY OF OXAZEPAM AND PENTACHLOROPHENOL

这个项目的目标是描述剂量反应的特征 五氯苯酚与奥沙西潘的关系及毒性研究 通过给老鼠喂剂量的饲料。将进行为期28天的研究，以 五氯苯酚为选择使用剂量提供数据 为期两年的慢性研究。对于奥沙西潘，为期2年的慢性研究将是 由于有足够的数据可供选择剂量，因此应立即进行。全 在测试期间，动物将被随意对待。 在每项研究结束时，所有动物都将被给予大体和显微观察。 组织病理学检查。血浆样本将从测试中获得 当天单次灌胃前和后8个时间点的动物 两项慢性研究中的尸检结果。然后将对这些样本进行评估 根据单独的合同测定血浆中的 测试化合物。

The objective of this project is to characterize dose-response relationships and toxicity of pentachlorophenol and oxazepam administered by dosed feed to rats. A 28-day study will be conducted for pentachlorophenol to provide data for the selection of doses to be used in the 2-year chronic study. For oxazepam, the 2-year chronic study will be conducted immediately since sufficient data for dose selection exist. All animals will be treated ad libitum during the course of the test period. At the end of each study, all animals will be given gross and microscopic histopathologic evaluations. Plasma samples are to be obtained from test animals prior to and at 8 timepoints after a single gavage dose on the day of necropsy in both chronic studies. These samples will then be evaluated under separate contract for determination of plasma concentrations of the test compounds.