Targeting conjugated markers with new metabolomic methods

检测天然类固醇的非法使用，如睾酮，或调节天然类固醇水平的化合物，仍然是所有形式的体育药物测试的最大挑战。该项目旨在开发基于液相色谱-高分辨率质谱的新代谢组学方法，以检测类固醇或类固醇调节剂给药后结合类固醇谱发生的变化。预期的结果将是一套敏感的分析方法，使用一系列新发现的结合类固醇标记物和相关的参考材料，这有望提高纯种赛马行业的完整性和动物福利。

Detecting the illicit use of natural steroids like testosterone, or compounds that modulate natural steroid levels, remains the greatest challenge for drug testing in all forms of sport. This project aims to develop new metabolomic methods based on liquid chromatography-high resolution mass spectrometry to detect the changes occurring in the conjugated steroid profile following the administration of steroids or steroid modulators. The intended outcome will be a set of sensitive and analytical methods using a range of newly identified conjugated steroid markers and associated reference materials, which promises to enhance integrity and animal welfare in the thoroughbred racing industry.