EPIDEMIOLOGY OF FRACTURES IN PERSONS OF AGE 45 AND OLDER

描述：(改编自《调查者摘要》)老年人骨折 人很普通，对生活质量有很大影响。 然而，对部位骨折的流行病学知之甚少。 髋部以外的，或白人以外的人群中的危险因素 女性。该建议描述了一项关于四肢骨折的病例对照研究。 前臂远端、脚远端、肱骨近端、骨盆和骨干。 45岁及以上的女性和男性的胫骨和腓骨 不同种族的人口。病例将在4年内确定 从皇帝的六个医学中心的成员资格开始的时间 北加州永久医疗保健计划。一个共同之处 对照组将用于五个病例组。控制将是 在与案件相同的4年期间内累算，它们将被 从按年龄和性别定义的阶层中随机选择 这六家医疗中心的会员资格。有关以下内容的最多信息 潜在的风险因素将通过标准化问卷获得 由训练有素的采访者管理。调查问卷将包括 人口统计特征，病史，骨折史， 功能状态，目前的健康状况，腿部神经病， 视力和听力、人体测量、生育史、体格检查 活动、吸烟、饮食选择、选择的方面 家庭环境，最近紧张的生活事件，社交网络， 认知功能，以及对事件的详细描述 围绕着骨折。视力和四肢检查 将应用神经病。医疗记录将被审查，以 所开的药物和经历过的疾病。骨密度， 脂肪质量和瘦身质量将通过双能x射线测量。 前臂远端骨折标本的骨密度测定 和控制力。统计分析将包括比较 各部位骨折的特点及对照 团体以及彼此之间的关系。导致坠落的特征 骨折将与对照组中没有导致骨折的跌倒进行比较 骨折。前臂远端和足部骨折的数量应该很多 足以大体考虑所有种族/民族群体的总和。这个 调查人员表示，这项研究应该增加我们的几个方面 骨折流行病学知识，从而提高我们的能力 建议采取预防措施。

DESCRIPTION: (Adapted from Investigator's Abstract) Fractures in older people are common and have a large impact on quality of life. Nevertheless, little is known of the epidemiology of fractures of sites other than the hip, or of risk factors in groups other than white females. The proposal describes a case-control study of fractures of the distal forearm, foot, proximal humerus, pelvis and shaft of the tibia and fibula among females and males of age 45 years and older in an ethnically diverse population. Cases will be identified over a 4-year period from the membership of six medical centers of the Kaiser Permanente Medical Care Program of Northern California. One common control group will be used for the five case groups. Controls will be accrued over the same 4-year period as the cases, and they will be selected at random from within strata defined by age and gender from the membership of these same six medical centers. Most information on potential risk factors will be obtained by a standardized questionnaire administered by trained interviewers. The questionnaire will cover demographic characteristics, medical history, fracture history, functional status, current health status, lower extremity neuropathy, vision and hearing, anthropometry, reproductive history, physical activity, cigarette smoking, selected aspects of diet, selected aspects of the home environment, recent stressful life events, social networks, cognitive function, and a detailed description of the events immediately surrounding the fracture. Tests for visual acuity and lower extremity neuropathy will be applied. Medical records will be reviewed for medications prescribed and illnesses experienced. Bone mineral density, fat mass, and lean body mass will be measured by dual energy x-ray absorptiometry (DEXA) in a sample of cases of distal forearm fracture and of controls. Statistical analysis will include comparing characteristics of cases with fracture of each site with the control group as well as with each other. Characteristics of falls leading to fractures will be compared with falls among the controls not leading to fracture. Numbers of distal forearm and foot fractures should be large enough to generally consider all racial/ethnic groups combined. The investigators state that this study should add to several aspects of our knowledge of fracture epidemiology, and thereby increase our ability to suggest preventive measures.