DIETARY & ENDOGENOUS ESTROGENS IN POSTMENOPAUSAL WOMEN

植物性食物摄入一直与较低的风险有关， 类固醇依赖性癌症。 特定的非营养植物化学物质， 如木脂素，在结构上与性类固醇激素相似，并可 因此在体内起作用以改变激素代谢和随后的癌症 风险 饮食在乳腺癌病因学中的作用还没有得到证实。 但由于大多数绝经后乳腺癌患者 涉及强烈的激素成分，很可能植物化学物质 可能会影响这种风险。 本提案的总体目标是探讨 膳食摄入富含木脂素的植物性食物对循环内源性 绝经后妇女的雌激素。 这项建议的具体目标是 确定是否：1）血清浓度和尿排泄的性别 激素和结合蛋白的影响亚麻籽摄入 在控制饮食的背景下摄入的生物标志物。 本研究将作为随机、交叉亚麻籽饲喂实施 审判 三十个绝经后的妇女，一个修道院的永久居民 他们的饭菜是在一个集中的厨房里准备的。 将给予受试者三种剂量的生亚麻籽，0、5和10 g/d 添加到他们准备好的食物中 会被抽血， 在每次7周喂养结束时，收集3天内的尿液 期间，当受试者吃他们通常的饮食时。 尿液和 血清木脂素（肠内酯、肠二醇、马台树脂酚和 将测量开环异落叶松树脂醛）以确定代谢， 排泄模式 血、尿性激素及性激素 将测量结合球蛋白，以确定 剂量的木脂素对激素的影响。 这项随机临床试验扩展了我们对女性健康的了解， 提供了更准确的信息来了解：1）流行病学 植物性食物摄入与乳腺癌之间的关联; 2）使用 饮食暴露标志物;和3）乳腺癌风险的潜在指标 其可以被监测用于癌症的初级预防。

Plant food intake has been consistently associated with lower risk for steroid hormone-dependent cancers. Specific non-nutrient phytochemicals, such as lignans, are similar in structure to sex steroid hormones and may therefore act in vivo to alter hormone metabolism and subsequent cancer risk. The role of diet in the etiology of breast cancer has not yet been determined, but because the majority of postmenopausal breast cancers involve a strong hormonal component, it is probable that phytochemicals may influence this risk. The overall objective of this proposal is to explore the effects of dietary intake of a lignan-rich plant food on circulating endogenous estrogens in postmenopausal women. Specific aims of this proposal are to determine whether: 1) serum concentrations and urinary excretion of sex hormones and binding proteins are influenced by flaxseed ingestion biomarkers of intake within the context of a controlled diet. This study will be implemented as a randomized, crossover flaxseed feeding trial. Thirty postmenopausal women, permanent residents of a convent whose meals are prepared in a centralized kitchen, will be recruited. Three doses, 0, 5, and 10 g/d, of raw flaxseed will be given to subjects each day to be added to their prepared food. Blood will be drawn and urine will be collected over 3 days at the end of each 7-week feeding period, and while subjects are eating their usual diets. Urinary and serum lignans (enterolactone, enterodiol, matairesinol, and secoisolariciresinal) will be measured to determine metabolism and excretion patterns. Serum and urinary sex hormones and sex hormone binding globulin will be measured to determine the effects of varying doses of lignans on hormone profiles. This randomized clinical trial expands our knowledge of women's health and provides more precise information to understand: 1) the epidemiologic associations between plant food intake and breast cancer; 2) the use of diet exposure markers; and 3) potential indicators of breast cancer risk which may be monitored for the primary prevention of cancer.